ArticleCureus2025
A Dilemma: Electrographic Seizure Activity in the Absence of Clinically Perceptible Seizures and the Ethical Challenges of Medical Decision-Making.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 37-year-old male with refractory left temporal epilepsy was admitted to the epilepsy monitoring unit to examine correlates of observable clinical seizure activity, those captured by responsive neurostimulation system (RNS) and continuous video electroencephalogram (cvEEG). The patient was diagnosed at age three, was on three anti-epileptic drugs, with an RNS implant since 2020 and was admitted to the epilepsy monitoring unit. The patient reported no seizures since 2019. cvEEG and RNS data were collected, and a comprehensive neuropsychological evaluation was conducted. cvEEG revealed brief electrographic activity originating from the left and right anterior temporal regions, occurring mainly on the left side. The activity was characterized ictally by prominent anterior temporal sharp waves, with a left-sided predominance. RNS data showed similar results but recorded electrographic activity in excess of cvEEG. Although clinical and electrographic manifestations tend to be stereotyped for seizures, there were no behavioral observations of clinical seizures during these recorded electrographic seizures on RNS data. The patient also reported no seizures. Neuropsychological results showed impairment across multiple cognitive domains. This case report highlights the need for a more detailed approach to determining allowable electrographic activity since these thresholds directly impact restrictions on patients with epilepsy. Highly sensitive measurement tools may better detect seizures, but in isolation, they cannot fully convey a complete picture of the patient's status without other data and clinical indicators. Data from emerging technology must be weighed in conjunction with clinical symptoms to optimize patient safety, quality of life, and outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.