Evidence map›Paper›PMID 40206927›Full record

ArticleCureus2025

Successful Use of Calcium Chloride in Acute Calcium Channel Blocker Overdose With Shock: A Case Report.

Shunsuke Nakamura, Natsuyo Shinohara

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shunsuke NakamuraDepartment of Emergency Medicine, Okayama Rosai Hospital, Okayama, JPN.
Natsuyo ShinoharaDepartment of Emergency Medicine, Okayama Rosai Hospital, Okayama, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium channel blockers (CCBs) are widely used to treat hypertension and tachyarrhythmias. However, an overdose can lead to severe toxicity, resulting in bradycardia, hypotension, and shock. Standard treatments, including calcium gluconate and catecholamines, may be ineffective in severe cases. This study reports a 60-year-old female with hypotensive shock following an intentional overdose of amlodipine. Despite the initial treatment with calcium gluconate, glucagon, and catecholamines, hemodynamic instability persisted. However, the intravenous administration of calcium chloride resulted in rapid hemodynamic improvement, allowing eventual recovery. This case highlights the potential of calcium chloride as a first-line antidote for severe CCBs overdose refractory to conventional treatments.

Indexed as

calcium channel blockers (ccbs)calcium chlorideoverdoseshocktoxicity

Identifiers

PMID40206927
PMCPMC11980017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.