ArticleRoyal Society open science2025
Stereocontrolled synthesis and nuclear magnetic resonance analysis of boranophosphate/phosphate chimeric oligonucleotides.
Article in Royal Society open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Stereocontrolled synthesis and nuclear magnetic resonance analysis of boranophosphate/phosphate chimeric oligonucleotides.Royal Society open science · 2025Article
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5 authors.
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Abstract
This report describes the stereoselective synthesis of boranophosphate/phosphate (PB/PO) chimeric oligodeoxynucleotides (ODNs) and the nuclear magnetic resonance (NMR) analysis of oligomers containing PB linkages. This stereoselective synthesis involved dimer building blocks containing highly stereopure boranophosphotriester linkages, which enabled the synthesis of PB/PO chimeric ODNs via the standard phosphoramidite method. The stereochemistry of dinucleoside and trinucleoside PBs was confirmed by nuclear Overhauser effect spectroscopy (NOESY) experiments. In the NOESY experiments, the stereochemistry was determined from the correlation of the protons of the borane (BH
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