ArticleExtracellular vesicles and circulating nucleic acids2025
Unraveling the role of amphisomes in mast cell secretory granule fusion and exosome release.
Article in Extracellular vesicles and circulating nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mast cells (MCs) play a crucial role in immune responses by storing and releasing inflammatory mediators from secretory granules (SGs). The biogenesis, maturation, and fusion of these granules with the plasma membrane regulate inflammation, immune cell recruitment, and tissue homeostasis. However, the exact mechanism underlying this process remains unclear. Recent studies have identified a novel mechanism of SG fusion involving amphisomes, hybrid organelles formed by the fusion of late endosomes and autophagosomes. This process not only facilitates SG enlargement but also promotes the release of exosomes, small vesicles crucial for intercellular communication and immune modulation. In particular, Omari
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