ArticleFrontiers in endocrinology2025
Nonlinear association of cardiometabolic index with hyperuricemia: insights from the NHANES 1999-2018 study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Dietary trace mineral intake and risk of all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stage 0-3: a cohort study.BMC public health · 2026Article
- Uricase deficiency in rats results in a variety of metabolic disorders, addition to gouty nephropathy.PloS one · 2025Article
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3 authors.
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Abstract
Background: Hyperuricemia, a risk factor for gout and cardiovascular diseases, has been linked to various metabolic disorders. This study investigates the association between the cardiometabolic index (CMI) and hyperuricemia. Methods: Using the National Health and Nutrition Examination Survey 1999-2018 data from 23,212 participants, we employed survey-weighted logistic regression to quantify the CMI-hyperuricemia relationship. Generalized additive models explored potential nonlinear relationships, with two-piecewise logistic regression identifying inflection points. Stratified analyses across demographic and health subgroups assessed relationship consistency. Results: We found a significant association between higher CMI and increased hyperuricemia and identified a nonlinear relationship, characterized by a faster risk increase at lower CMI levels and slower at higher levels. This pattern remained consistent across all demographic and health subgroups. Conclusions: Higher CMI significantly predicts hyperuricemia across diverse populations, with a pronounced nonlinear association. This pattern underscores the importance of early intervention, emphasizing the need for personalized risk assessments and targeted strategies.
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