Evidence map›Paper›PMID 40206511›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2024

Diffusion MRI with Machine Learning.

Davood Karimi, Simon K Warfield

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. A detailed spatiotemporal atlas of the white matter tracts for the fetal brain.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Davood KarimiHarvard Medical School and Boston Children's Hospital, Boston, Massachusetts, USA.
Simon K WarfieldHarvard Medical School and Boston Children's Hospital, Boston, Massachusetts, USA.

Funding

Acquisition of a Siemens 3T MRI for Research ImagingS10OD025111 · OD · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2018 to 2018
$2.0M
Enabling the Assessment of Fetal Brain Development and Degeneration with Machine LearningR01NS128281 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Davood Karimi · 2023 to 2026
$1.8M
Accurate, reliable, and interpretable machine learning for assessment of neonatal and pediatric brain micro-structureR01HD110772 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Davood Karimi · 2023 to 2026
$1.5M
Machine learning algorithms to analyze large medical image datasetsR01LM013608 · NLM · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2021 to 2024
$1.5M
NICHD NIH HHS R01 HD110772NIH HHS S10 OD025111NINDS NIH HHS R01 NS128281NLM NIH HHS R01 LM013608
6 · The paper itself

Abstract

Diffusion-weighted magnetic resonance imaging (dMRI) of the brain offers unique capabilities including noninvasive probing of tissue microstructure and structural connectivity. It is widely used for clinical assessment of disease and injury, and for neuroscience research. Analyzing the dMRI data to extract useful information for medical and scientific purposes can be challenging. The dMRI measurements may suffer from strong noise and artifacts, and may exhibit high inter-session and inter-scanner variability in the data, as well as inter-subject heterogeneity in brain structure. Moreover, the relationship between measurements and the phenomena of interest can be highly complex. Recent years have witnessed increasing use of machine learning methods for dMRI analysis. This manuscript aims to assess these efforts, with a focus on methods that have addressed data preprocessing and harmonization, microstructure mapping, tractography, and white matter tract analysis. We study the main findings, strengths, and weaknesses of the existing methods and suggest topics for future research. We find that machine learning may be exceptionally suited to tackle some of the difficult tasks in dMRI analysis. However, for this to happen, several shortcomings of existing methods and critical unresolved issues need to be addressed. There is a pressing need to improve evaluation practices, to increase the availability of rich training datasets and validation benchmarks, as well as model generalizability, reliability, and explainability concerns.

Indexed as

Artificial IntelligenceDeep LearningDiffusion MRIMachine Learning

Identifiers

PMID40206511
PMCPMC11981007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.