Evidence map›Paper›PMID 40206430›Full record

ArticleLiver research (Beijing, China)2025

Probiotic Bifidobacterium reduces serum TMAO in unstable angina patients via the gut to liver to heart axis.

Zhihong Zhou, Lizhe Sun, Wei Zhou, Wen Gao, Xiao Yuan, Huijuan Zhou, Yuzhen Ren, Bihua Li, Yue Wu, Jianqing She

Abstract read
In one paragraph

Article in Liver research (Beijing, China), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhihong ZhouDepartment of Cardiology, Bayannur Hospital, Bayannur, Inner Mongolia Autonomous Region, China.
Lizhe SunDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wei ZhouDepartment of Cardiology, Wuzhong People's Hospital, Wuzhong, Ningxia, China.
Wen GaoDepartment of Cardiology, Bayannur Hospital, Bayannur, Inner Mongolia Autonomous Region, China.
Xiao YuanDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Huijuan ZhouDepartment of Cardiology, Bayannur Hospital, Bayannur, Inner Mongolia Autonomous Region, China.
Yuzhen RenDepartment of Cardiology, Bayannur Hospital, Bayannur, Inner Mongolia Autonomous Region, China.
Bihua LiDepartment of Cardiology, Bayannur Hospital, Bayannur, Inner Mongolia Autonomous Region, China.
Yue WuDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jianqing SheDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: Studies indicate that the gut microbiota and its metabolites are involved in the progression of cardiovascular diseases, and enterohepatic circulation plays an important role in this progression. This study aims to identify potential probiotics for the treatment of unstable angina (UA) and elucidate their mechanisms of action. Methods: Initially, the gut microbiota from patients with UA and control was analyzed. To directly assess the effects of Results: After supplementing with Conclusions: Metagenomic analysis demonstrated a reduced abundance of Clinical trial number: ChiCTR2400093946.

Indexed as

BifidobacteriumGut–liver–heart axisTrimethylamine N-oxide (TMAO)Unstable angina pectoris

Identifiers

PMID40206430
PMCPMC11977283

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.