ArticleInfection and drug resistance2025
Treatment with Ceftazidime-Avibactam for Lower Respiratory Tract Infections Caused by the Multidrug-Resistant Gram-Negative Bacteria in the Intensive Care Unit.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Ceftazidime avibactam (CAZ-AVI) is recommended for treating severe infections caused by multidrug-resistant gram-negative bacteria (MDR-GNB). However, there are few real-world studies on the use of CAZ-AVI to treat lower respiratory tract infections (LRTIs) caused by MDR-GNBs in intensive care units (ICUs). This study aimed to evaluate the clinical characteristics of patients with LRTIs caused by MDR-GNB who were treated with CAZ-AVI in the ICU, and to investigate the independent risk factors for mortality. Patients and Methods: This single-center retrospective study included patients with LRTIs treated with CAZ-AVI in the respiratory ICU of a tertiary hospital in Anhui Province between December 2022 and November 2024. The primary outcomes were 28-day survival and independent risk factors for all-cause mortality. Results: A total of 71 patients were enrolled in the study and 56.3% (40/71) had 28-day survival outcomes. The Acute Physiology and Chronic Health Evaluation (APACHE) II score (odds ratio [OR]: 1.144, 95% confidence interval [CI]: 1.012-1.293, p=0.032), coinfection with Conclusion: CAZ-AVI can be used to treat LRTIs caused by MDR-GNB in the ICU. Higher APACHE II scores and coinfection with Aspergillus were associated with 28-day mortality, whereas a longer course of therapy was a protective factor. The nomogram can help clinicians predict CAZ-AVI outcomes.
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