ArticleOphthalmology science
OCT-Based Retinal Vasculature Analysis: Age, Sex, and Body Mass Index Associations in the Nagahama Study, a Large Japanese Cohort.
Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Morphometric Analysis of Retinal Vessels Using High-Resolution OCT Technology in Healthy Subjects.Investigative ophthalmology & visual science · 2026Observational
- Retinal microstructural disorganization in persistent macular edema secondary to branch retinal vein occlusion: an adaptive optics OCT study.Scientific reports · 2026Observational
- Retinal arteriovenous crossings as spatiotemporal stress fields: a quantitative Doppler OCT flowmetry study.Scientific reports · 2026Article
- Age-Related Associations of Blood Pressure and Arterial Stiffness with Retinal Arterial Structure.Ophthalmology science · 2026Article
- Multimodal Imaging of Yellow-White Transformation in Chorioretinal Hemorrhages: Structural and Biochemical Insights.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to evaluate retinal vessel structure using OCT, which enables high-resolution imaging for detailed vascular assessment. We investigated how age, sex, and body mass index (BMI) influence the OCT-measured parameters, including outer and inner diameters (ODs and IDs, respectively), wall thickness, and wall reflectivity-parameters that are challenging to assess using color fundus photography. Design: A cross-sectional retrospective study. Participants: The study included 6981 participants in the Nagahama Study, with 6981 eyes being assessed. Methods: OCT B-scan images centered on the optic disc were obtained. For each participant, mean values of the ODs and IDs, wall thickness, and wall reflectivity of the 4 largest arteries and veins were measured. Main Outcome Measures: Associations of retinal vessel parameters with age, sex, and BMI were evaluated. The reliability of OCT-measured parameters was assessed using intraclass correlation coefficients. Multivariable linear regression adjusted for intraocular pressure and axial length was used to investigate the associations with demographic and anthropometric factors. Results: Intraclass correlation coefficients for retinal vessel parameters demonstrated good-to-excellent reliability (0.767-0.957, Conclusions: OCT enabled detailed evaluation of retinal vessel structure, allowing for the measurement of parameters that are challenging to assess by fundus photography, such as IDs and ODs, wall thickness, and wall reflectivity. This study, conducted in a large Japanese cohort, demonstrated significant associations between these OCT-measured retinal vascular parameters and age, sex, and BMI. These findings support the potential of OCT as a valuable tool for objective, in-depth assessment of retinal vascular health and its relationships with demographic and anthropometric factors. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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