Evidence map›Paper›PMID 40206143›Full record

ArticleMaterials today. Bio2025

Bufotalin loaded biomimetic nanodrug for combined chemo/photodynamic therapy of cancer.

Simin Chen, Jialong Fan, Qian Xie, Yan Qin, Hailong Xie, Chang Xiao, Wei Wang, Bin Liu

Abstract read
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Simin ChenCollege of Biology, Hunan University, Changsha, 410082, China.
Jialong FanCollege of Biology, Hunan University, Changsha, 410082, China.
Qian XieHunan Provincial Maternal and Child Health Care Hospital, Hunan Province, Changsha 410008, China.
Yan QinCollege of Biology, Hunan University, Changsha, 410082, China.
Hailong XieHunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Institute of Cancer Research, School of Medicine, University of South China, Hengyang, 421001, China.
Chang XiaoCollege of Biology, Hunan University, Changsha, 410082, China.
Wei WangTCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China.
Bin LiuCollege of Biology, Hunan University, Changsha, 410082, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combination of chemotherapy and photodynamic therapy (PDT) for enhancing cancer therapeutic efficiency has attracted tremendous attention recently. However, limitations, such as low local concentration and uncontrollable release of therapeutic agents, reduce combined treatment efficacy. In the present study, we engineered a biomimetic nanodrug employing hollow Prussian blue nanoparticles (HPB NPs) to co-load the chemical agent bufotalin (CS-5) and the photosensitizer chlorin e6 (Ce6) for combined chemo/PDT therapy against cancer. HPB NPs with catalase (CAT)-mimetic activity significantly improved the efficacy of PDT by catalyzing the decomposition of H

Indexed as

BufotalinCancerChlorin e6Combination therapyPrussian blue nanoparticles

Identifiers

PMID40206143
PMCPMC11979420

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.