Evidence map›Paper›PMID 40206069›Full record

ArticleFrontiers in pharmacology2025

Effect of sheep placenta extract on D-galactose-induced aging mouse.

Shan He, Yue Wu, Kaixian Lu, Heng Zhu, Xuan Wang, Yaoyao Qin, Huan Li, Lin Zeng, Jiaojiao Han, Xiangyang Zhou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shan HeCollege of Food and Bioengineering, Bengbu University, Bengbu, China.
Yue WuCollege of Food and Bioengineering, Bengbu University, Bengbu, China.
Kaixian LuCollege of Food and Bioengineering, Bengbu University, Bengbu, China.
Heng ZhuCollege of Food and Bioengineering, Bengbu University, Bengbu, China.
Xuan WangCollege of Food and Bioengineering, Bengbu University, Bengbu, China.
Yaoyao QinCollege of Food and Bioengineering, Bengbu University, Bengbu, China.
Huan LiCollege of Food and Bioengineering, Bengbu University, Bengbu, China.
Lin ZengCollege of Food and Bioengineering, Bengbu University, Bengbu, China.
Jiaojiao HanSchool of Marine Sciences, Ningbo University, Ningbo, China.
Xiangyang ZhouGenepioneer Biotechnologies Co., Ltd., Nanjing, China.
Bin ZhangCollege of Food and Bioengineering, Bengbu University, Bengbu, China.
Bo TangCollege of Food and Bioengineering, Bengbu University, Bengbu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Sheep placenta extract (SPE) is a representative traditional medicinal substance that exhibits multiple experimentally validated physiological properties, including anti-aging effects, wound healing acceleration, antioxidant activity, and anti-inflammatory mechanisms. However, the mechanism by which SPE influences the delay of aging is still not yet clear. Methods: Exploring the effects of sheep placenta extract on D-gal induced senescence in a mouse model of aging by macrogenomics and metabolomics. Results: In the serum of aging mice treated with SPE, the levels of antioxidant function such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) were notably higher compared to those in the blank group, whereas malondialdehyde (MDA) levels decreased. We revealed that SPE alleviated the changes in gut microbiota caused by aging in mice, with a significant decrease in the Discussion: The role of SPE in ameliorating aging may be associated with the increased abundance of A. muciniphila in the gut microbiota and the accumulation of two metabolites, EPA and triptolide, in the serum.

Indexed as

anti-agingantioxidantD-galactosegut microbiotasheep placenta extract

Identifiers

PMID40206069
PMCPMC11979192

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.