ArticleFrontiers in molecular biosciences2025
Urinary marker of oxidative stress in children correlates with molecules in exhaled breath.
Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Real-time breath metabolomics as catalyst for personalized lung cancer diagnostics: prospective matched case-control trial (LUCAbreath).Translational lung cancer research · 2026Article
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7 authors.
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Abstract
Real-time breath analysis has shown potential as a non-invasive method for detecting oxidative stress and airway inflammation. However, there is a lack of data on the association of full-breath profiles with established urinary biomarkers of oxidative stress and respiratory inflammation, which could help advance the implementation of this method in clinical practice. We analyzed breath profiles of 25 tobacco smoke-exposed and 103 non-exposed children via real-time secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) and determined in parallel the urinary concentrations of biomarkers of oxidative stress and respiratory inflammation. We evaluated the correlation between breath features and urinary biomarkers and tested the prediction of these biomarkers by exhaled breath. We found 71 breath features that correlated significantly with the urinary oxidative stress marker 8-iso-prostaglandin F2α (8-iso-PGF2α). The agreement (mean ± standard deviation) (Lin's concordance correlation) between breath-predicted and actual urinary 8-iso-PGF2α levels was 0.37 (0.05). In conclusion, our results suggest that the real-time breath analysis via SESI-HRMS has promising potential to gauge oxidative stress.
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