ReviewTherapeutic delivery2025
The progress of hyaluronic acid's application in therapeutic delivery.
Review in Therapeutic delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A novel integratedRegenerative biomaterials · 2026Article
- Advances in hyaluronic acid hydrogel for meniscus repair.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid (HA) is a widely available, bio-compatible, polysaccharide with unique physical and chemical properties, which have inspired its application in many fields. Firstly, HA is a significant representative in wound healing, embryonic development, repair as well as regeneration. Secondly, HA exhibits pregnant meaning in cancer progression. Tumor cell proliferation, invasiveness, and motility can be modulated by the accumulation of HA in tumor stoma. Thirdly, HA is an actor in regulation processes during the angiogenesis. The level of HA, even low-molecular-weight HA, is considered to be a biomarker of tumor malignancy. Within this work, an intense overview of its application and the use of HA in drug delivery systems is given.HA plays a crucial role in many cases, such as cell signaling, morphogenesis, matrix organization, tissue regeneration, and pathobiology. Biocompatibility, mucoadhesivity, hygroscopicity, biodegradability, and viscoelasticity are to mention as physico-chemical properties of hyaluronan. This is why exogenous HA is investigated for drug delivery systems and exhibits a representative therapy of cancer, esthetic medicine, rhinology, arthrology, and cosmetics.In the end, the proof of concept presented by clinical trials is convincing to further investigate native HA as well as modified one for therapeutic delivery purposes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.