Evidence map›Paper›PMID 40205763›Full record

ArticleInternational journal of stem cells2025

Functional Validation of Alcohol Dependence-Associated

Bilal Cakir, Yoshiaki Tanaka, Mu Seog Choe, Pei-Yu Chu, Yangfei Xiang, Kun-Yong Kim, Mei Zhong, Joel Gelernter, Huiping Zhang, John Krystal and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bilal CakirDepartment of Genetics, Yale Stem Cell Center, Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-4610-0317
Yoshiaki TanakaDepartment of Genetics, Yale Stem Cell Center, Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-2078-9374
Mu Seog ChoeDepartment of Genetics, Yale Stem Cell Center, Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-4826-895X
Pei-Yu ChuDepartment of Genetics, Yale Stem Cell Center, Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT, USA.
Yangfei XiangDepartment of Genetics, Yale Stem Cell Center, Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-6256-6312
Kun-Yong KimDepartment of Genetics, Yale Stem Cell Center, Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-8968-0177
Mei ZhongDepartment of Cell Biology, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-1230-0775
Joel GelernterDepartment of Genetics, Yale Stem Cell Center, Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-4067-1859
Huiping ZhangDepartments of Psychiatry and Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4902-0104
John KrystalDepartments of Psychiatry and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-6952-1726
In-Hyun ParkDepartment of Genetics, Yale Stem Cell Center, Child Study Center, Wu Tsai Institute, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-7748-1293

Funding

Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
Construction of the integrated human forebrain organoids to investigate neurodevelopmental disordersR01MH118344 · NIMH · YALE UNIVERSITY · PI In-Hyun Park · 2019 to 2026
$4.0M
NIAAA NIH HHS P50 AA012870NIMH NIH HHS R01 MH118344
6 · The paper itself

Abstract

Alcohol dependence (AD) is one of the most prevalent neuropsychiatric disorders. Multiple polymorphisms in the Fyn tyrosine kinase gene (

Indexed as

Alcohol dependenceNeuronsNGN2rs706895Stem cells

Identifiers

PMID40205763
PMCPMC12394083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.