ArticleJournal of separation science2025
Enantioseparation of Mirabegron Using Cyclodextrin-based Chiral Columns: High-performance Liquid Chromatography and Molecular Modeling Study.
Article in Journal of separation science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Chiral separation of aromatic amino acids by capillary electrophoresis using sulphated β-cyclodextrin as a single chiral selector: an experimental and computational study.RSC advances · 2026Article
- Enantioselective Properties of Neglected Drug Nifurtimox on Polysaccharide and Macrocyclic Glycopeptide Chiral Stationary Phases by Green HPLC Separation Methods.Journal of separation science · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A novel high-performance liquid chromatography method for the enantioseparation of mirabegron (R-mirabegron), a selective β-3 adrenergic receptor agonist, using cyclodextrin (CD)-based chiral stationary phases (CSPs) was developed. Seven different CSPs containing β-, γ-, hydroxypropyl-β-, sulfobutyl-β-, carboxymethyl-β-, permethyl-β-, and phenylcarbamate-β-cyclodextrin were evaluated under both polar organic and reversed-phase conditions. Only the phenylcarbamate-β-cyclodextrin containing the Chiral CD-Ph column displayed enantiorecognition. Optimization of conditions using a full factorial design led to the determination of the most suitable conditions: a mobile phase composition of 90:10:0.1 methanol:water:diethylamine, a flow rate of 0.8 mL/min, and a column temperature of 40°C with enantiomeric elution order, where the impurity S-mirabegron elutes first. Using the optimized conditions, enantioseparation with R
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