ArticleJournal of medicinal chemistry2025
Selective Inhibition of Rat α7 Nicotinic Acetylcholine Receptors by LvID, a Newly Characterized α4/7-Conotoxin from
Man Guo, Xiaopeng Zhu, Tao Ma, Chenxing Xu, Dongting Zhangsun, Jinpeng Yu, Quentin Kaas, Peta J Harvey, J Michael McIntosh, David J Craik and 1 more
Abstract read
In one paragraphArticle in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Man GuoGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Xiaopeng ZhuGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.ORCID 0000-0001-8830-4954 Tao MaGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Chenxing XuGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Dongting ZhangsunGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Jinpeng YuGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Quentin KaasInstitute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID 0000-0001-9988-6152 Peta J HarveyInstitute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID 0000-0003-4735-6242 J Michael McIntoshDepartment of Biology and Psychiatry, University of Utah, Salt Lake City, Utah 84112, United States.
David J CraikInstitute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID 0000-0003-0007-6796 Sulan LuoGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.ORCID 0000-0002-3568-5797 Funding
Development and Application of Nicotinic Acetylcholine Receptor Targeted Peptides for Biomedical ResearchR35GM136430 · NIGMS · UNIVERSITY OF UTAH · PI MCINTOSH, J MICHAEL · 2020 to 2024
$2.3MNIGMS NIH HHS R35 GM136430
6 · The paper itselfAbstract
The α7 nicotinic acetylcholine receptors (nAChRs), identified in peripheral and central nervous systems, are crucial for cognitive function, memory, inflammation, and are linked to disorders like Alzheimer's disease (AD), lung cancer, myasthenia gravis, and atherosclerosis. Here we report that a novel α4/7-conotoxin (CTx) LvID, from
Indexed as
alpha7 Nicotinic Acetylcholine ReceptorConotoxinsConus SnailNicotinic AntagonistsAnimalsOocytesRatsStructure-Activity RelationshipXenopus laevisalpha7 Nicotinic Acetylcholine ReceptorConotoxinsNicotinic Antagonists
Identifiers
PMID40205658
PMCPMC13489617
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