Evidence map›Paper›PMID 40205649›Full record

ArticleJournal of applied clinical medical physics2025

An investigation into the feasibility and efficacy of stereotactic radiosurgery for 1-3 cm single brain lesions on the ring-mounted Halcyon LINAC.

Kate Hazelwood, Shane McCarthy, Josh Misa, David Castelvetere, William St Clair, Damodar Pokhrel

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kate HazelwoodMedical Physics Graduate Program, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.
Shane McCarthyMedical Physics Graduate Program, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0009-0001-9300-4857
Josh MisaMedical Physics Graduate Program, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0009-0007-8084-0438
David CastelvetereMedical Physics Graduate Program, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.
William St ClairMedical Physics Graduate Program, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.
Damodar PokhrelMedical Physics Graduate Program, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0003-2694-1047

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAn evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1-3 cm) brain lesions.

methodsAfter completing the extensive in-house quality assurance checks including Winston-Lutz test and independent dose verification via MD Anderson IROC SRS head phantom irradiation on Halcyon, fifteen brain SRS patients previously treated with a single dose of 20 Gy on TrueBeam (6MV-FFF) with HyperArc geometry were retrospectively replanned on Halcyon (6MV-FFF). Plan quality metrics including conformity index (CI), gradient index (GI), gradient distance (GD), PTV coverage, gross tumor volume (GTV) dose, heterogeneity index (HI), and doses to organs-at-risk (OAR) including normal brain dose were evaluated. Patient-specific quality assurance (PSQA) and independent dose verification via in-house Monte Carlo (MC) 2nd checks were performed.

resultsThe Halcyon was able to provide highly conformal brain SRS plans. When compared to TrueBeam, CI, planning target volume (PTV) coverage, GTV dose (mean and minimum), HI, and doses to brainstem, optic pathway, and cochlea were statistically insignificant. Statistically significant increases in GI (3.76 vs. 3.25, p < 0.001), GD (0.56 cm vs. 0.48 cm, p = 0.001), and V

conclusionsHalcyon brain SRS plans provided a similar plan quality compared to HyperArc plans, although it demonstrated an inferior intermediate dose fall off thus slightly higher V

Indexed as

Brain NeoplasmsOrgans at RiskParticle AcceleratorsPhantoms, ImagingRadiosurgeryRadiotherapy Planning, Computer-AssistedFeasibility StudiesHumansMonte Carlo MethodQuality Assurance, Health CareRadiotherapy DosageRadiotherapy, Intensity-ModulatedRetrospective Studiesco/non‐planar geometryHalcyon LINACHyperArcsmall brain lesionSRSVMAT

Identifiers

PMID40205649
PMCPMC12148757

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.