Evidence map›Paper›PMID 40205612›Full record

ArticleBMC veterinary research2025

Lumpy skin disease virus ORF142 protein inhibits type I interferon production by disrupting interactions of TBK1 and IRF3.

Zihan Chen, Jingyu Wang, Baochun Lu, Heyu Li, Chuanli Liu, Huijuan Zeng, Jinping Chen, Shizhe Liu, Qifeng Jiang, Kun Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zihan ChenCollege of Veterinary Medicine, South China Agricultural University, Guangdong, 510642, China.
Jingyu WangCollege of Veterinary Medicine, South China Agricultural University, Guangdong, 510642, China.
Baochun LuCollege of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Heyu LiCollege of Veterinary Medicine, South China Agricultural University, Guangdong, 510642, China.
Chuanli LiuCollege of Veterinary Medicine, South China Agricultural University, Guangdong, 510642, China.
Huijuan ZengCollege of Veterinary Medicine, South China Agricultural University, Guangdong, 510642, China.
Jinping ChenCollege of Veterinary Medicine, South China Agricultural University, Guangdong, 510642, China.
Shizhe LiuCollege of Veterinary Medicine, South China Agricultural University, Guangdong, 510642, China.
Qifeng JiangCollege of Veterinary Medicine, South China Agricultural University, Guangdong, 510642, China.
Kun JiaCollege of Veterinary Medicine, South China Agricultural University, Guangdong, 510642, China. jiakun@scau.edu.cn.

Funding

Guangzhou Municipal Science and Technology Project 202206010131
6 · The paper itself

Abstract

backgroundLumpy skin disease virus (LSDV) causes lumpy skin disease, which is one of the most devastating ruminant diseases. The pathogenesis of the disease remains largely unknown; however, the disease seriously threatens the global cattle-farming industry. In our previous study, we found that LSDV 142 gene deletion affected LSDV proliferation in cells and was an early gene involved in LSDV infection. Additionally, the study found that ORF142 inhibits the production of interferon beta.

resultsHerein, we report that LSDV inhibits the host antiviral response. The results revealed that the LSDV ORF142 protein inhibited interferon-promoter activation. ORF142 suppresses the host antiviral response by blocking interferon beta (IFN-β) production based on 381-417 amino acids at the C-terminal domain site of interferon regulatory factor 3 (IRF3). ORF142 interacts with IRF3 and interferes with the recruitment of IRF3 to TANK-binding kinase 1 (TBK1) in a dose-dependent manner, preventing nuclear translocation of IRF3.

conclusionsThese results suggest that LSDV ORF142 antagonizes host antiviral innate immunity by affecting the binding between TANK-binding kinase 1 and IRF3. Our findings provide new information regarding the pathogenesis of this virus.

Indexed as

Interferon Regulatory Factor-3Interferon Type ILumpy skin disease virusProtein Serine-Threonine KinasesViral ProteinsAnimalsCattleHEK293 CellsHumansInterferon-betaLumpy Skin DiseaseInterferon-betaInterferon Regulatory Factor-3Interferon Type IProtein Serine-Threonine KinasesViral ProteinsImmune evasionIRF3LSDVORF142TBK1

Identifiers

PMID40205612
PMCPMC11984027

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.