ArticleBMC pulmonary medicine2025
Airway inflammation, bronchial hyperresponsiveness, and anti-asthma therapy responses in cough variant asthma and classic asthma with FEV
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed.
- From Susceptibility to Severity: The Impact of Interleukin-33 rs1929992 Polymorphism on Asthma in a Taiwanese Population.Life (Basel, Switzerland) · 2026Article
- From Susceptibility to Disease Severity: Re-Discovering the Clinical Role ofLife (Basel, Switzerland) · 2026Article
- Corticosteroids in asthma and COPD: an inflammopharmacological perspective on molecular and genetic determinants.Molecular biology reports · 2026Review
- Type 2 Inflammation in Asthma and COPD: Biomarkers, Clinical Applications, and Targeted Therapies.Journal of inflammation research · 2026Review
- Disparities in Cough Variant Asthma Management and Physician-Reported Pulmonary Function Testing Resources: A Cross-Sectional Survey of Respiratory Physicians Across Hospital Tiers in Zhejiang, China.Journal of asthma and allergy · 2026Article
- Combined prediction of fractional exhaled nitric oxide and pulmonary function tests for airway hyperresponsiveness in children with chronic cough.Translational pediatrics · 2025Article
- Associations of Matrix Metalloproteinase-7 Promoter Genotypes With Asthma Risk in Taiwan.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo explore the differentiation of airway inflammation, bronchial hyperresponsiveness and anti-asthma therapy responses between the cough variant asthma (CVA) and classic asthma (CA) patients with FEV
methodsIn the first monocentre retrospective cross-sectional study, 402 patients with suspicion of CA and 544 patients with chronic cough were enrolled. Further prospective monocentre study was conducted and 66 patients of suspected asthma with negative bronchial dilation test (BDT) but positive bronchial challenge (BCT) test were enrolled and followed up for 4 weeks.
resultsCA patients had higher fractional exhaled nitric oxide (FENO) values than CVA patients (36.0 ppb vs. 24.0 ppb, p < 0.0001). The predictive value of FENO for positive BCT was significantly lower in chronic cough patients compared to those with suspicion of CA (AUC = 0.603 vs. 0.728). Following four weeks anti-asthma therapy, both the CVA and CA groups showed significant improvement in both the large and small airway function and symptom relief. There was no significant difference between the respective groups. The two most valuable spirometric variables for predicting a positive response to anti-asthma treatment were the improvements of FEV
conclusionPatients with CVA exhibited lower levels of airway eosinophilic inflammation compared to those with mild CA. Most patients with mild CA and CVA could benefit promptly from anti-asthma treatment. Additionally, an improvement in FEV
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