ArticleBMC endocrine disorders2025
Comparison of triglyceride glucose index and other insulin resistance indexes in children with overweight and obesity.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Triglyceride-glucose index identifies early metabolic stress and β-cell vulnerability in pediatric obesity.World journal of pediatrics : WJP · 2026Article
- Assessing the Diagnostic Performance of Triglyceride-Glucose-Based Indices for Early Detection of Metabolic Syndrome in Paediatric Down Syndrome.Journal of intellectual disability research : JIDR · 2026Article
- Metabolic dysfunction and insulin resistance across major dementias: A comprehensive narrative review of the TyG index as a predictive marker.Metabolism open · 2026Review
- Prediabetes in children and adolescents in Israel: a large-scale retrospective cohort study.European journal of pediatrics · 2026Article
- Diagnostic Accuracy of the Triglyceride-Glucose Derived Indices in Detecting Metabolic Syndrome in Pediatric Patients.Journal of obesity & metabolic syndrome · 2026Article
- PODiaCarD: a prototype of a digital twin platform for the management of pediatric obesity and related cardiometabolic complications.European journal of pediatrics · 2026Article
- The associations of systemic inflammation and insulin resistance-related indicators with psychopathology and BDNF in patients with chronic schizophrenia.Frontiers in psychiatry · 2026Article
- Anthropometric and Metabolic Determinants of Multi-Organ Stress in Adults with Obesity: Application of the CaRaMeL-O Score.Healthcare (Basel, Switzerland) · 2025Article
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Abstract
objectivesThe aim of the study was to determine the correlation between insulin resistance (IR) indexes in children with overweight or obesity.
methodsA total of 276 children with overweight or obesity and 100 normal-weight children were enrolled in the study. IR indexes such as homeostasis model assessment insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), fasting glucose/insulin ratio (FGIR), Triglyceride glucose index (TyG), and lipid-derived ratios were determined.
resultsThe mean ages were 13.0 ± 2.6, 13.1 ± 2.7 and 12.72 ± 2.23 (range:6 - 18 years) for children with overweight, obesity and normal-weight, respectively. A statistically significant positive correlation was found between HOMA-IR and TyG index, and a negative correlation between QUICKI, FGIR and TyG index (r = 0.193, P < 0.001; r = - 0.456, P < 0.001 and r = - 0.392, P < 0.001, respevtively). TyG index, triglyceride (TG)/high-density lipoprotein (HDL), total cholesterol (TC)/HDL, and low-density lipoprotein (LDL)/HDL were higher in children with IR than those without IR (P < 0.05). In receiver operating characteristic curves analysis, cut-off points were found to be ≤ 0.31 for QUICKI (94.31% sensitivity and 97.58% specificity), ≤ 6.3 for FGIR (89.1% sensitivity and 93.94% specificity), and > 4.62 for TyG (49.29% sensitivity and 84.85% specificity).
conclusionHOMA-IR, FGIR, and QUICKI constitute stronger predictors of IR than TyG index in children with overweight and obesity.
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