Evidence map›Paper›PMID 40205532›Full record

ArticleBMC ophthalmology2025

Clinical characteristics and risk factors for readmission after deep anterior lamellar keratoplasty: a nationwide, cross-sectional, multicenter study.

Chenxi Wang, He Xie, Binjia Sun, Kexin Tang, Haiou Wang, Zelin Zhao, Qinxiang Zheng, Jie Wu, Qi Zhang, Baihua Chen and 25 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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35 authors.

Chenxi Wang *Department of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
He Xie *Department of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Binjia SunDepartment of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Kexin TangDepartment of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Haiou WangDepartment of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zelin ZhaoDepartment of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Qinxiang ZhengDepartment of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jie WuDepartment of Ophthalmology, Xi'an No. 1 Hospital, No. 30, Fen Alley, South Street, Xi'an, Shaanxi, China.
Qi ZhangDepartment of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Baihua ChenDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
He DongDepartment of Ophthalmology, The Third People's Hospital of Dalian & Dalian Municipal Eye Hospital, Dalian, Liaoning, China.
Jizhong YangDepartment of Cornea, Shanxi Eye Hospital, Taiyuan, Shanxi, China.
Hai LiuDepartment of Ophthalmology, Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, China.
Feng WenDepartment of Ophthalmology, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China.
Tao SunDepartment of Ophthalmology, Jiangxi Province Division of National Clinical Research Center of Ocular Disease, The Affiliated eye hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Jinsong XueDepartment of Ophthalmology, The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Shaozhen ZhaoCorneal & Refractive surgery center, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Limin ChenDepartment of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Zhirong LiuDepartment of Ophthalmology, Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yanning YangDepartment of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Xunlun ShengDepartment of Ophthalmology, Ningxia Eye Hospital, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical College of Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan, China.
Pengcheng WuDepartment of Ophthalmology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Yuping HanDepartment of Cornea, Shanxi Eye Hospital, Taiyuan, Shanxi, China.
Wei QiangDepartment of Ophthalmology, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China.
Qi XieDepartment of Ophthalmology, Jiangxi Province Division of National Clinical Research Center of Ocular Disease, The Affiliated eye hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Yingnan XuDepartment of Ophthalmology, The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Hui LiuCorneal & Refractive surgery center, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Man YuDepartment of Ophthalmology, Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Linying HuangDepartment of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Huiping LiDepartment of Ophthalmology, Ningxia Eye Hospital, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical College of Ningxia Medical University, Ningxia Hui Autonomous Region, Yinchuan, China.
Ruifen WeiDepartment of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Minye WangDepartment of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Gang ChenFirst People's Hospital of Aksu, Aksu, Xinjiang, China.
Yan ChengDepartment of Ophthalmology, Xi'an No. 1 Hospital, No. 30, Fen Alley, South Street, Xi'an, Shaanxi, China. kathycheng0918@163.com.
Wei ChenDepartment of Ophthalmology, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. chenweimd@wmu.edu.cn.

Funding

Central Government-guided Local Science and Technology Development Fund Project of Xinjiang Uygur Autonomous Region ZYYD2024CG16National Key R&D Program of China 2019YFC0840708Science and Technology Plan Project of Wenzhou Municipality Y20211005Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-037AZhejiang Province Leading Geese Plan 2023C03G2092659
6 · The paper itself

Abstract

backgroundTo assess the incidence, cause and risk factors for unplanned readmission within 90 days after deep anterior lamellar keratoplasty (DALK).

methodsA multicentre cross-sectional study of 3603 eyes of 3588 patients after keratoplasty between January 1st, 2019, and September 30th, 2021 in 16 hospitals across China was performed. The demographic and clinical features between patients after DALK with 90-day unplanned readmission and those who did not have been compared. The risk factors of unplanned readmission were identified by a multivariable Cox regression model.

resultsAmong 873 patients (878 eyes) after DALK, and the primary indications for DALK were keratitis (391 eyes, 44.53%) and keratoconus (275 eyes, 31.32%). The rates of unplanned readmission within 30 days, 60 days, and 90 days were 1.95%, 4.01%, and 5.15%. The main reason of 90-day readmission was infectious keratitis (18 eyes, 40.00%), followed by corneal epithelial defects (11 eyes, 24.44%) and immune-related keratitis (10 eyes, 22.22%). Patients readmitted within 90 days exhibit a more advanced age (p = 0.013). It is also more concentrated in patients with corneal ulcers or perforations (p = 0.029) or blindness (p = 0.02). Compared with patients with keratoconus, patients with keratitis (HR = 3.545, 95% CI 1.104-11.386, p = 0.034) and corneal degeneration or malnutrition (HR = 6.470, 95% CI 1.942-21.560, p = 0.002) are more likely to have an unplanned readmission risk within 90 days.

conclusionThe main causes of unplanned readmission within 90 days after DALK were infectious keratitis, corneal epithelial defects, and immune-related keratitis. The indications for DALK were associated with 90-day readmissions. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Corneal DiseasesCorneal TransplantationPatient ReadmissionPostoperative ComplicationsAdolescentAdultAgedChinaCross-Sectional StudiesFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsDeep anterior lamellar keratoplastyRisk factorsUnplanned readmission

Identifiers

PMID40205532
PMCPMC11984012

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