ArticleBMC psychiatry2025
Optical coherence tomography in patients with major depressive disorder.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic narrative review of the form, process, and function of sensory hyposensitivity in depression.Translational psychiatry · 2026Pooled it
- Seeing Through Feeling: Dynamic Interplay Between Emotion and Visual Perception.Brain sciences · 2026Review
- Associations between retinal morphological features and risk of depression and anxiety disorders.BMC medicine · 2026Article
- Self images: an empirical enquiry into Rembrandt's self-portraits.Frontiers in psychiatry · 2026Article
- Central retinal volume derived from optical coherence tomography as a potential predictor of mortality in the old-aged population- results from the German AugUR study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
backgroundOptical coherence tomography (OCT) has emerged as a significant non-invasive imaging technique in psychiatric research, allowing for detailed structural assessment of the retinal layers. While OCT has been promising for monitoring neurodegeneration in Alzheimer's and Parkinson's diseases, results in major depressive disorder (MDD) remain inconsistent. Building on findings of attenuated electroretinogram (ERG) responses in MDD, indicating functional retinal alterations, this study investigated whether structural retinal changes, such as thinning of retinal layers, also occur in patients with MDD and whether these changes are associated with the severity of depressive symptoms.
methodsOCT examinations were conducted on 31 MDD patients and 60 healthy controls (HC). The thickness and volumes of macular retinal layers were analyzed and correlated with depressive symptoms.
resultsThe thickness of the outer nuclear layer (ONL) was significantly reduced in MDD patients (p = 0.003) and negatively correlated with depressive symptoms (BDI-II scores; p = 0.001). The thickness and volume of the ganglion cell and inner plexiform layer were further inversely associated with depressive symptoms in MDD patients (BDI-II and MADRS scores; p < 0.02).
conclusionsONL thinning in MDD suggests possible neurodegenerative processes that may disturb signal transmission downstream, as indicated by altered ERG responses in MDD. Further research is essential to determine the reversibility of these structural changes following remission. Structural retinal analysis with OCT offers the potential to complement functional ERG examinations and represents a promising approach for developing diagnostic and therapeutic monitoring tools for MDD.
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