Evidence map›Paper›PMID 40205298›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025

Clinical phenotypes and outcomes associated with improved left ventricular ejection fraction after biventricular pacing.

Sameer A Kunte, Lurdes Y T Inoue, William T Abraham, John G F Cleland, Anne B Curtis, Daniel J Friedman, Michael R Gold, Valentina Kutyifa, Cecilia Linde, Anthony S Tang and 2 more

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In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sameer A KunteDivision of Cardiology, Duke University School of Medicine, Durham, NC, USA. sameer.kunte@duke.edu.ORCID http://orcid.org/0000-0002-5235-5941
Lurdes Y T InoueDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
William T AbrahamDivision of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.
John G F ClelandBritish Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom.
Anne B CurtisDepartment of Medicine, University at Buffalo, Buffalo, NY, USA.
Daniel J FriedmanDivision of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Michael R GoldDepartment of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Valentina KutyifaDivision of Cardiology, Department of Medicine, University of Rochester Medical Center Rochester, Rochester, NY, USA.
Cecilia LindeKarolinska Institutet and Department of Cardiology, Karolinska University, Stockholm, Sweden.
Anthony S TangDepartment of Medicine, Western University, London, ON, Canada.
Gillian D SandersDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Sana M Al-KhatibDivision of Cardiology, Duke University School of Medicine, Durham, NC, USA.

Funding

Power of Bayesian Methods, RCTs, and Decision Models to Inform CRT UncertaintiesR01HL131754 · NHLBI · DUKE UNIVERSITY · PI SCHMIDLER, GILLIAN SANDERS · 2017 to 2020
$2.7M
NHLBI NIH HHS 1R01HL131754NHLBI NIH HHS R01 HL131754
6 · The paper itself

Abstract

backgroundIn some patients who receive a cardiac resynchronization therapy (CRT) device, the left ventricular ejection fraction (LVEF) does not improve.

methodsWe analyzed patients enrolled in the REVERSE, MADIT-CRT, and BLOCK-HF trials, restricting the analysis to those who received CRT. Characteristics of patients with or without improved LVEF were compared using two sample t-tests and Pearson's chi-square tests. Kaplan-Meier survival curves were constructed to display time-to-event data. A log-rank test was used to compare event rates for patients with or without improved LVEF. Mixed effects Cox Proportional-Hazards models adjusting for covariates were used to analyze time to death or heart failure hospitalization (HFH) and time to death.

resultsOf 1065 included patients, 75% (802) were men, 87% (793) were White, 11% (118) were Black, and 7% (72) were Hispanic. LVEF improved in 910 (85%) patients and did not in 155 (15%). Patients with an improved LVEF were less likely to have ischemic cardiomyopathy (ICM) (54% vs 76%; p = 0.004), more likely to have LBBB (73% vs 53%; p = < 0.001), and had longer QRS duration (159 vs 150 ms; p = < 0.001). In adjusted analyses, improved LVEF was associated with a longer time to HFH or death (HR 0.40; 95% CI 0.26-0.62; p < 0.001) or death alone (HR 0.27; 95% CI 0.15-0.48; p < 0.001).

conclusionsPatients with improvement in LVEF post-CRT implantation are less likely to have ICM and more likely to have LBBB and a longer QRS interval. Improvement in LVEF was associated with better outcomes.

Indexed as

Cardiac Resynchronization TherapyHeart FailureStroke VolumeVentricular Dysfunction, LeftAgedFemaleHumansMaleMiddle AgedPhenotypeRisk AssessmentSurvival RateTreatment OutcomeBiventricular pacingCRTHeart failureLVEF

Identifiers

PMID40205298
PMCPMC12354237

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.