SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Baseline functioning scales of quality of life (EORTC QLQ-C30) as a predictor of overall survival in patients with lung cancer: a meta-analysis.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing the impact of neoadjuvant chemotherapy and chemoradiotherapy on quality of life during treatment in esophageal cancer: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Pooled it
- Health behaviors and symptom clusters mediate self-management efficacy and quality of life in lung cancer immunotherapy.Scientific reports · 2026Article
- Quality of Life and Its Psychosocial Determinants Among Cancer Patients: Insights from the Qassim Region, Saudi Arabia.Healthcare (Basel, Switzerland) · 2026Article
- Stage IIIB ROS1-Positive NSCLC management: crizotinib + surgery + TCM achieves exceptionally prolonged PFS (a case report).Frontiers in pharmacology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundStudies have shown inconsistent associations between quality of life (QoL) and survival in patients with lung cancer (LC).
objectiveTo assess the association between baseline functioning scales from the EORTC QoL Questionnaire Core 30 (QLQ-C30) and overall survival in patients with LC by conducting a meta-analysis.
methodsTwo independent authors searched PubMed and Embase databases using the following PECOS criteria: population (patients with pathological diagnosis of LC), exposure (poor health-related QoL, as measured by the functioning scales of EORTC QLQ-C30), comparator (better QoL), outcomes (overall survival), and study design (cohort studies).
resultsSixteen studies with 9429 patients were identified. Compared to the highest scores, the lowest scores on the global QoL (hazard ratios [HR] 1.59; 95% confidence intervals [CI] 1.38-1.84), physical functioning (HR 1.58; 95% CI 1.24-2.03), role functioning (HR 1.43; 95% CI 1.19-1.73), and emotional functioning (HR 1.29; 95% CI 1.05-1.60) scales significantly predicted poorer overall survival. A 10-point increase in the global QoL, physical functioning, and role functioning scales was associated with a reduced risk of mortality (HR 0.87; 95% CI 0.84-0.91, HR 0.88; 95% CI 0.85-0.92, and HR 0.93; 95% CI 0.87-0.99, respectively). However, 10-point increases in the emotional functioning (HR 0.97; 95% CI 0.92-1.01), cognitive functioning (HR 0.97; 95% CI 0.95-1.00), and social functioning (HR 0.95; 95% CI 0.90-1.01) scales did not significantly predict overall survival.
conclusionsBaseline QoL, specifically lower scores on the global QoL, physical functioning, and role functioning scales of the EORTC QLQ-C30, significantly predicts poorer overall survival in patients with LC.
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