ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Intensive care unit-acquired rectal colonization and subsequent infections with carbapenem-resistant bacteria: a cross-sectional study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeNosocomial infections caused by carbapenem-resistant bacteria (CRB) present a worldwide threat. We examined the incidence and clinical outcomes of ICU-acquired gastrointestinal colonization with CRB detected through routine weekly surveillance of rectal swabs.
methodsThis retrospective study included adult patients admitted to the ICU between January 1, 2020 and December 31, 2022, whose rectal swab cultures yielded CRB colonization after at least 72 h of ICU admission.
resultsOf 4,673 eligible patients, 493 had at least one positive rectal swab culture for CRB (prevalence 10.5%) after a mean of 17.8 days from ICU admission. The most common CRB species was Klebsiella pneumoniae (41.8%), followed by Acinetobacter baumannii (32.3%), Pseudomonas aeruginosa (21.3%) and Escherichia coli (8.1%). Following colonization, 240 patients (48.7%) developed CRB infections after a mean of 11.4 days and 29.2 days from the first positive rectal culture and from ICU admission, respectively. The overall agreement between the baseline rectal and final cultures was 82.1%. CRB-infected patients had higher frequencies of burns at baseline (p < 0.001), carbapenem (p = 0.015) and colistin (p < 0.001) use during ICU stay, need for intubation (p = 0.002) and nasogastric tube (p = 0.021), prolonged ICU stay (p < 0.001), and mortality (p = 0.006).
conclusionOur findings showed that nearly one in every 10 ICU patients acquired CRB colonization despite preventive efforts, ending up with CRB infections in nearly half.
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