Evidence map›Paper›PMID 40205214›Full record

ArticleNature2025

Functional connectomics spanning multiple areas of mouse visual cortex.

MICrONS Consortium

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 213 papers.

0numbers the graph read from it
0cells of the map it votes in
213citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

213 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  15. Microglia extract neuronal proteolytic organelles via skoupocytosis.bioRxiv : the preprint server for biology · 2026
    Article
  16. Review
  17. Dendritic morphology and synaptic nonlinearities enhance functional complexity in human cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Article
  19. Article
  20. Article

153 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

MICrONS Consortium

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7M
Subcortical Neural Coding and DynamicsU19NS104648 · NINDS · PRINCETON UNIVERSITY · PI BRODY, CARLOS D · 2017 to 2021
$15.3M
Collaboratory for atlasing cell type anatomy in the female and male mouse brainU01MH114824 · NIMH · COLD SPRING HARBOR LABORATORY · PI MITRA, PARTHA PRATIM · 2017 to 2021
$11.7M
Boss: A cloud-based data archive for electron microscopy and x-ray microtomographyR24MH114785 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BROCK A. WESTER · 2018 to 2026
$6.9M
Circuit Mechanisms Underlying Persistent Activity in a Neural IntegratorR01EY027036 · NEI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Emre R Aksay, MARK S GOLDMAN · 2016 to 2026
$6.4M
Structure and Function of a Cubic Millimeter of Cortex: Crowdsourcing for Proofreading and DiscoveryRF1MH123400 · NIMH · PRINCETON UNIVERSITY · PI SEUNG, HYUNJUNE SEBASTIAN · 2020 to 2020
$6.4M
Virtual Observatory of the Cortex: Organelles, Cells, Circuits, and DynamicsU24NS120053 · NINDS · ALLEN INSTITUTE · PI Forrest Christie Collman, Nuno Macarico da Costa · 2022 to 2026
$6.1M
Scalable integration of cell types and connectivity in the motor cortex of rodents and non-human primatesRF1MH128840 · NIMH · ALLEN INSTITUTE · PI COLLMAN, FORREST CHRISTIE, MACARICO DA COSTA, NUNO · 2021 to 2021
$4.2M
Circuit Mechanisms Underlying Learned Changes in Persistent Neural ActivityR01NS104926 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI AKSAY, EMRE R, GOLDMAN, MARK S · 2018 to 2022
$4.1M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
NEI NIH HHS R01 EY027036NIMH NIH HHS R24 MH114785NIMH NIH HHS RF1 MH117815NIMH NIH HHS RF1 MH123400NIMH NIH HHS RF1 MH128840NIMH NIH HHS U01 MH114824NIMH NIH HHS U19 MH114830NINDS NIH HHS R01 NS104926NINDS NIH HHS U19 NS104648NINDS NIH HHS U24 NS120053
6 · The paper itself

Abstract

Understanding the brain requires understanding neurons' functional responses to the circuit architecture shaping them. Here we introduce the MICrONS functional connectomics dataset with dense calcium imaging of around 75,000 neurons in primary visual cortex (VISp) and higher visual areas (VISrl, VISal and VISlm) in an awake mouse that is viewing natural and synthetic stimuli. These data are co-registered with an electron microscopy reconstruction containing more than 200,000 cells and 0.5 billion synapses. Proofreading of a subset of neurons yielded reconstructions that include complete dendritic trees as well the local and inter-areal axonal projections that map up to thousands of cell-to-cell connections per neuron. Released as an open-access resource, this dataset includes the tools for data retrieval and analysis

Indexed as

ConnectomePrimary Visual CortexVisual CortexAnimalsAxonsCalciumDendritesFemaleMaleMiceMice, Inbred C57BLNeuronsSynapsesCalcium

Identifiers

PMID40205214
PMCPMC11981939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.