SynthesisEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2025
Do clinical caries-preventive interventions applied to expectant mothers affect caries-related parameters in their children? A systematic review.
Synthesis in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
purposeTo assess whether caries-preventive clinical interventions targeted exclusively to expectant mothers reduce caries experience or various surrogate parameters associated with caries activity in their children.
methodSeven databases were searched for randomised clinical trials until November 2024. Studies assessing clinical caries-preventive measures in healthy expectant mothers and comparing them to placebo, other, or no interventions. Outcomes measured in children included caries experience and surrogate parameters (e.g., S. mutans levels), patient-reported, and socioeconomic data. Non-randomized studies as well as, behavioural and educational interventions were excluded. Risk of bias was assessed using the Cochrane Collaboration's RoB 2 tool.
resultsOut of the 2149 studies identified, only 5 studies were included. Two of them presented with low risk of bias, whereas there were some concerns for the other three. The assessed outcomes included either caries experience directly (percentage of caries active children, DMFT, DMFS, dmft, dmfs) or the Streptococcus mutans levels. Children in the experimental groups showed significantly lower S. mutans levels compared to controls. Regarding caries levels, the results were contradictory. The supplementation of calcium in expectant mothers resulted in caries reductions in their offsprings, while sodium fluoride with potassium iodine topical applications or vitamin D supplementation were not shown to be effective.
conclusionClinical caries-preventive interventions applied to expectant mothers might result in reduced S. mutans levels in their children. Further studies are warranted to provide additional evidence, especially with regards to caries experience. REGISTRATION: Research Registry: reviewregistry1047.
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