Trial reportEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2025
Clinical performance of two chemomechanical caries removal agents in primary molars: a randomized controlled trial.
Trial report in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05427591 (Clinical and Microbiological Evaluation of the Chemo-mechanical Caries Removal Agent), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Microbiological Evaluation of the Chemo-mechanical Caries Removal Agent (BRIX3000®) in Primary Molars: A Randomized Controlled Clinical Trial.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy of chemomechanical caries removal and conventional mechanical caries removal for the treatment of primary molar caries in children: a meta-analysis.BMC oral health · 2026Pooled it
- Comparison of the Efficiency of the Carie-Care and Bromelain Gel, as Chemomechanical Caries Removal Techniques in Primary Teeth: Randomized Controlled Clinical Trial.International journal of clinical pediatric dentistry · 2026Article
- Pain perception and treatment time of chemo mechanical versus conventional caries removal techniques in pediatric dental patients.Bioinformation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeThe concept of Chemomechanical Caries Removal (CMCR) includes the selective removal of caries-infected tissue while preserving caries-affected tissue. However, studies examining its application to children are scarce. The aim was to assess pain perception and time duration of CMCR agents when removing caries in primary molars in a sample of children compared to the conventional method of caries removal using rotary burs.
methodsA randomized controlled clinical trial with a split-mouth design with a sample of 60 children aged 4-9 years with 120 cavitated occlusal carious primary molars was equally distributed into 2 experiments: BRIX3000
resultsCaries removal using the conventional method was significantly faster compared to CMCR agents in both experiments (P < 0.001 and P < 0.001). Caries removal using BRIX3000
conclusionThe study concluded that although CMCR methods require more time for caries removal, they were reported to be less painful.
trial registrationThe study protocol was registered at www. CLINICALTRIALS: gov under the identifier NCT05427591.
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Registered trials
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