Evidence map›Paper›PMID 40205125›Full record

SynthesisInternational urology and nephrology2025

Long-term renal function post-pyeloplasty: a systematic review.

Roberto B I Christanto, Putu Angga Risky Raharja, Gerhard Reinaldi Situmorang, Irfan Wahyudi, Arry Rodjani, Abubakr Imam, Tariq Abbas

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Current Status and Future Perspectives of Robotic-Assisted Redo Pyeloplasty for Recurrent Ureteropelvic Junction Obstruction.International journal of urology : official journal of the Japanese Urological Association · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Roberto B I ChristantoDepartment of Urology. Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Putu Angga Risky RaharjaDepartment of Urology. Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia. anggariskyraharja@gmail.com.
Gerhard Reinaldi SitumorangDepartment of Urology. Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Irfan WahyudiDepartment of Urology. Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Arry RodjaniDepartment of Urology. Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Abubakr ImamNephrology Division, Sidra Medical and Research Center, Doha, Qatar.
Tariq AbbasPediatric Urology Division, Sidra Medical and Research Center, Doha, Qatar. tariq2c@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUreteropelvic junction obstruction (UPJO) is a significant cause of functional impairment in neonatal kidneys. The gold-standard surgical intervention for UPJO is pyeloplasty, which offers good preservation of kidney function, but long-term renal outcomes and the durability of surgical correction are not fully understood. This systematic review aims to assess the long-term impact of pyeloplasty on renal function, quality-of-life, and complication rates among pediatric patients.

methodsA comprehensive search of PubMed, Embase, Scopus, and Cochrane Library was conducted to retrieve studies reporting long-term outcomes (≥ 2 years) of pediatric pyeloplasty. Inclusion criteria focused on renal function metrics including differential renal function (DRF), estimated glomerular filtration rate (eGFR), and imaging findings. 9 studies encompassing n = 836 patients met inclusion criteria. Data were synthesized narratively due to significant heterogeneity of methods and reporting.

resultsMost studies reported significant improvements in renal function post-pyeloplasty, particularly in cases with low preoperative DRF (< 20%). DRF improvements ranged from 5 to 15%, with preservation or enhancement of renal function observed in up to 89% of cases. Hydronephrosis resolution and increases in renal parenchymal thickness were also reported frequently. Minimally invasive approaches, such as retroperitoneoscopic one-trocar-assisted pyeloplasty, showed comparable efficacy to open techniques. Complications were predominantly minor, including transient urinary infections and stent-related discomfort, with no significant long-term morbidity noted across studies.

conclusionPyeloplasty demonstrates durable success in improving or preserving renal function in pediatric patients with UPJO. Early intervention, particularly in cases diagnosed antenatally, yields the best outcomes. While all surgical techniques reviewed were effective, minimally invasive approaches offer reduced operative times and faster recovery. Further research should aim to standardize evaluation protocols and explore the use of novel biomarkers to enhance long-term patient monitoring.

Indexed as

KidneyKidney PelvisUreteral ObstructionUrologic Surgical ProceduresChildGlomerular Filtration RateHumansQuality of LifeTime FactorsLong-termPyeloplastyRenal functionUreteropelvic junction obstruction

Identifiers

PMID40205125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.