ArticleNature methods2025
CAVE: Connectome Annotation Versioning Engine.
Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Sticking the landing: leg mechanosensory feedback coordinates the transition from flight to landing.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells.Nature neuroscience · 2026Article
- Synaptic Organization of the Primate Retina: Toward a Human Foveal Connectome.Annual review of vision science · 2026Review
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- Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina.bioRxiv : the preprint server for biology · 2026Article
- Cell-type-specific parallel pathways in the canonical cortical microcircuit.bioRxiv : the preprint server for biology · 2026Article
- Connectome simulations identify a central pattern generator circuit for fly walking.bioRxiv : the preprint server for biology · 2026Article
- vEMRec: High-Resolution Volume Electron Microscopy Reconstruction Based on Structure-Preserving and High-Fidelity 3D Alignment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury.Cell · 2026Article
- A multi-resolution imaging and analysis pipeline for comparative circuit reconstruction in insects.bioRxiv : the preprint server for biology · 2026Article
- Proprioceptive limit detectors contribute to sensorimotor control of the Drosophila leg.Nature communications · 2026Article
- A neural connectivity atlas for fly flight control.Current biology : CB · 2026Article
- Synaptic-resolution connectomics: towards large brains and connectomic screening.Nature reviews. Neuroscience · 2026Review
- Connectome of a human foveal retina.bioRxiv : the preprint server for biology · 2026Article
- The grand challenge in cellular neurophysiology.Frontiers in cellular neuroscience · 2026Article
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- Uncertainty quantification for connectomics.Nature methods · 2025Article
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Authors and funding
42 authors.
Funding
Abstract
Advances in electron microscopy, image segmentation and computational infrastructure have given rise to large-scale and richly annotated connectomic datasets, which are increasingly shared across communities. To enable collaboration, users need to be able to concurrently create annotations and correct errors in the automated segmentation by proofreading. In large datasets, every proofreading edit relabels cell identities of millions of voxels and thousands of annotations like synapses. For analysis, users require immediate and reproducible access to this changing and expanding data landscape. Here we present the Connectome Annotation Versioning Engine (CAVE), a computational infrastructure that provides scalable solutions for proofreading and flexible annotation support for fast analysis queries at arbitrary time points. Deployed as a suite of web services, CAVE empowers distributed communities to perform reproducible connectome analysis in up to petascale datasets (~1 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.