ArticleNature2025
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
–field-weighted citation impact
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Who cites it
22 citing papers in PubMed.
- Article
- The structure of the native cardiac crossbridge in the rigor state.Science advances · 2026Article
- Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.Journal of medicinal chemistry · 2026Article
- Why labelling the 'fast-reacting thiols' of myosin reduces force output: re-assessing a year at the University of California San Francisco (1987-8).Biophysical reviews · 2026Review
- Impact of salt concentration and free magnesium on human beta-cardiac myosin reveal important details about the conserved mechanochemical mechanism.The Journal of biological chemistry · 2026Article
- Mavacamten inhibits myosin activity by stabilizing the myosin interacting-heads motif and stalling motor force generation.Science advances · 2026Article
- Assessing the Performance of BioEmu in Understanding Protein Dynamics.International journal of molecular sciences · 2026Article
- Editorial: Release of inorganic phosphate from the myosin active site in actomyosin energy transduction.Frontiers in physiology · 2026Article
- Structure of the Myosin Thick Filaments in Muscle.Sub-cellular biochemistry · 2026Review
- Experimentally achieving minimal dissipation via thermodynamically optimal transport.Nature communications · 2025Article
- Theoretical treatment of tension transients in muscle following sudden changes in orthophosphate concentration: implications for energy transduction.Journal of muscle research and cell motility · 2025Article
- The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders.International journal of molecular sciences · 2025Review
- Freeze frame: cracking molecular motion.Nature · 2025Article
- Advances in microfluidic mixers for time-resolved structural biology with X-rays.Biophysical reviews · 2025Review
- The elementary step that generates force and sinusoidal analysis in striated muscle fibers.Journal of muscle research and cell motility · 2025Review
- Modulation of Filopodial Myosin Function.bioRxiv : the preprint server for biology · 2025Article
- The order of things: phosphate release or the power stroke, which does actomyosin do first?Frontiers in physiology · 2025Review
- A mechanokinetic actomyosin model predicts different orthophosphate sensitivities of force and ATP turnover rate during isometric muscle contraction.Frontiers in physiology · 2025Article
- Dynamics of the Pre-Powerstroke Myosin Lever Arm and the Effects of Omecamtiv Mecarbil.International journal of molecular sciences · 2024Article
- Human cardiac β-myosin powerstroke energetics: Thin filament, Pi displacement, and mutation effects.Biophysical journal · 2024Article
Corrections and comments
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Authors and funding
15 authors.
David P Klebl *School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Sean N McMillan *Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
Cristina RisiDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
Eva ForgacsDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
Betty VirokDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
Jennifer L AthertonDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.
Sarah A HarrisSchool of Mathematical and Physical Sciences, University of Sheffield, Sheffield, UK.
Michele StofellaAstbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
Donald A WinkelmannDepartment of Pathology & Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.
Frank SobottAstbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.ORCID 0000-0001-9029-1865
Vitold E GalkinDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA.ORCID 0000-0003-1138-7565
Peter J KnightAstbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.ORCID 0000-0002-8850-9500
Stephen P MuenchSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK. s.p.muench@leeds.ac.uk.ORCID 0000-0001-6869-4414
Charlotte A ScarffAstbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. c.a.scarff@leeds.ac.uk.ORCID 0000-0001-6168-0060
Howard D WhiteDepartment of Biomedical and Translational Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, VA, USA. whitehd@ODU.edu.ORCID 0000-0003-1066-2051
Funding
Structure of the Prepowerstroke Conformation of Actomyosin-ADP-Pi by Time-Resolved Cryo-EMR21AR071675 · NIAMS · EASTERN VIRGINIA MEDICAL SCHOOL · PI GALKIN, VITOLD, WHITE, HOWARD D. · 2018 to 2019
$363kNIAMS NIH HHS R21 AR071675UK Engineering and Physical Sciences Research CouncilUniversity of LeedsWellcome Trust
Abstract
Myosins produce force and movement in cells through interactions with F-actin
Indexed as
Cryoelectron MicroscopyMyosinsActinsActomyosinAdenosine TriphosphateAnimalsHydrolysisModels, MolecularPhosphatesProtein BindingProtein DomainsTime FactorsActinsActomyosinAdenosine TriphosphateMyosinsPhosphates
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.