Evidence map›Paper›PMID 40205052›Full record

ArticleNature2025

Complete sequencing of ape genomes.

DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A Logsdon, Steven J Solar, Dmitry Antipov, Brandon D Pickett, Yana Safonova, Francesco Montinaro and 113 more

Abstract readComparative Study
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed.

  1. Characterization of immunoglobulin loci inNAR genomics and bioinformatics · 2026
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  15. Germline hypomethylation shapes dynamic CpG reservoirs in ape genomes.bioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

123 authors.

DongAhn YooDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0003-0033-3721
Arang RhieGenome Informatics Section, Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9809-8127
Prajna HebbarUC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID 0009-0008-9817-5330
Francesca AntonacciDepartment of Biosciences, Biotechnology and Environment, University of Bari, Bari, Italy.ORCID 0000-0002-5833-6186
Glennis A LogsdonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0003-2396-0656
Steven J SolarGenome Informatics Section, Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Dmitry AntipovGenome Informatics Section, Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Brandon D PickettGenome Informatics Section, Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8235-4440
Yana SafonovaComputer Science and Engineering Department, Huck Institutes of Life Sciences, Pennsylvania State University, State College, PA, USA.ORCID 0000-0002-9634-4216
Francesco MontinaroDepartment of Biosciences, Biotechnology and Environment, University of Bari, Bari, Italy.ORCID 0000-0002-4506-963X
Yanting LuoDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0003-1227-8512
Joanna MalukiewiczResearch Unit for Evolutionary Immunogenomics, Department of Biology, University of Hamburg, Hamburg, Germany.
Jessica M StorerInstitute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Jiadong LinDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Abigail N SequeiraDepartment of Biology, Penn State University, University Park, PA, USA.ORCID 0000-0003-4093-1654
Riley J ManganComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Glenn HickeyUC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID 0000-0002-2280-9404
Graciela Monfort AnezStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0009-0004-3369-2987
Parithi BalachandranThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Anton BankevichComputer Science and Engineering Department, Huck Institutes of Life Sciences, Pennsylvania State University, State College, PA, USA.
Christine R BeckInstitute for Systems Genomics, University of Connecticut, Storrs, CT, USA.ORCID 0000-0001-7821-8489
Arjun BiddandaDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-1861-1523
Matthew BorchersStowers Institute for Medical Research, Kansas City, MO, USA.
Gerard G BouffardNIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8744-6440
Emry BrannanDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Shelise Y BrooksNIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Lucia CarboneDepartment of Medicine, KCVI, Oregon Health Sciences University, Portland, OR, USA.ORCID 0000-0002-2118-107X
Laura CarrelPSU Medical School, Penn State University School of Medicine, Hershey, PA, USA.ORCID 0000-0002-5868-4228
Agnes P ChanThe Translational Genomics Research Institute, City of Hope National Medical Center, Phoenix, AZ, USA.ORCID 0000-0003-2373-9580
Juyun CrawfordNIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0006-4430-7751
Mark DiekhansUC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID 0000-0002-0430-0989
Eric EngelbrechtDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, USA.
Cedric FeschotteDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Giulio FormentiVertebrate Genome Laboratory, The Rockefeller University, New York, NY, USA.
Gage H GarciaDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0009-0005-2383-722X
Luciana de GennaroDepartment of Biosciences, Biotechnology and Environment, University of Bari, Bari, Italy.
David GilbertSan Diego Biomedical Research Institute, San Diego, CA, USA.ORCID 0000-0001-8087-9737
Richard E GreenDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID 0000-0003-0516-5827
Andrea GuarracinoDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0001-9744-131X
Ishaan GuptaDepartment of Computer Science and Engineering, University of California, San Diego, San Diego, CA, USA.
Diana HaddadNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Junmin HanBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Robert S HarrisDepartment of Biology, Penn State University, University Park, PA, USA.
Gabrielle A HartleyInstitute for Systems Genomics, University of Connecticut, Storrs, CT, USA.ORCID 0000-0002-5672-2171
William T HarveyDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Michael HillerLOEWE Centre for Translational Biodiversity Genomics, Frankfurt, Germany.ORCID 0000-0003-3024-1449
Kendra HoekzemaDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Marlys L HouckSan Diego Zoo Wildlife Alliance, Escondido, CA, USA.
Hyeonsoo JeongDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Kaivan KamaliDepartment of Biology, Penn State University, University Park, PA, USA.
Manolis KellisComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-7113-9630
Bryce KilleDepartment of Computer Science, Rice University, Houston, TX, USA.
Chul LeeLaboratory of Neurogenetics of Language, The Rockefeller University, New York, NY, USA.
Youngho LeeLaboratory of Bioinformatics and Population Genetics, Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.
William LeesDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, USA.ORCID 0000-0001-9834-6840
Alexandra P LewisDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Qiuhui LiDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Mark LoftusDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.ORCID 0000-0002-6279-6855
Yong Hwee Eddie LohNeuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, USA.
Hailey LoucksUC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.
Jian MaRay and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0002-4202-5834
Yafei MaoBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-9648-4278
Juan F I MartinezComputer Science and Engineering Department, Huck Institutes of Life Sciences, Pennsylvania State University, State College, PA, USA.
Patrick MastersonNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Rajiv C McCoyDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-0615-146X
Barbara McGrathDepartment of Biology, Penn State University, University Park, PA, USA.
Sean McKinneyStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0002-9740-6247
Britta S MeyerResearch Unit for Evolutionary Immunogenomics, Department of Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0002-2549-1825
Karen H MigaUC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID 0000-0002-3670-4507
Saswat K MohantyDepartment of Biology, Penn State University, University Park, PA, USA.
Katherine M MunsonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-8413-6498
Karol PalDepartment of Biology, Penn State University, University Park, PA, USA.
Matt PennellDepartment of Computational Biology, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-2886-3970
Pavel A PevznerDepartment of Computer Science and Engineering, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0002-0418-165X
David PorubskyDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-8414-8966
Tamara PotapovaStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0003-2761-1795
Francisca R RingelingFaculty of Informatics and Data Science, University of Regensburg, Regensburg, Germany.
Joana L RochaDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-3266-6328
Oliver A RyderSan Diego Zoo Wildlife Alliance, Escondido, CA, USA.ORCID 0000-0003-2427-763X
Samuel SaccoDepartment of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.
Swati SahaDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, USA.ORCID 0009-0004-7210-6338
Takayo SasakiSan Diego Biomedical Research Institute, San Diego, CA, USA.ORCID 0000-0001-7609-9316
Michael C SchatzDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-4118-4446
Nicholas J SchorkThe Translational Genomics Research Institute, City of Hope National Medical Center, Phoenix, AZ, USA.ORCID 0000-0003-0920-5013
Cole ShanksUC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.
Linnéa SmedsDepartment of Biology, Penn State University, University Park, PA, USA.ORCID 0000-0002-8415-9259
Dongmin R SonDepartment of Ecology, Evolution and Marine Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, USA.ORCID 0009-0001-6806-7258
Cynthia SteinerSan Diego Zoo Wildlife Alliance, Escondido, CA, USA.
Alexander P SweetenGenome Informatics Section, Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5316-2973
Michael G TassiaDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-5485-8155
Françoise Thibaud-NissenNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4957-7807
Edmundo Torres-GonzálezDepartment of Biology, Penn State University, University Park, PA, USA.
Mihir TrivediDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Wenjie WeiSchool of Life Sciences, Westlake University, Hangzhou, China.
Julie WertzDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0009-0000-3747-3221
Muyu YangRay and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Panpan ZhangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Shilong ZhangBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.ORCID 0009-0000-8844-2273
Yang ZhangRay and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Zhenmiao ZhangDepartment of Computer Science and Engineering, University of California, San Diego, San Diego, CA, USA.
Sarah A ZhaoComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0008-6068-5693
Yixin ZhuDepartment of Computational Biology, Cornell University, Ithaca, NY, USA.
Erich D JarvisLaboratory of Neurogenetics of Language, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-8931-5049
Jennifer L GertonStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0003-0743-3637
Iker Rivas-GonzálezDepartment of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Benedict PatenUC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID 0000-0001-8863-3539
Zachary A SzpiechDepartment of Biology, Penn State University, University Park, PA, USA.
Christian D HuberDepartment of Biology, Penn State University, University Park, PA, USA.ORCID 0000-0002-2267-2604
Tobias L LenzResearch Unit for Evolutionary Immunogenomics, Department of Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0002-7203-0044
Miriam K KonkelDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.ORCID 0000-0002-3190-1667
Soojin V YiDepartment of Ecology, Evolution and Marine Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, USA.ORCID 0000-0003-1497-1871
Stefan CanzarFaculty of Informatics and Data Science, University of Regensburg, Regensburg, Germany.ORCID 0000-0003-4719-8010
Corey T WatsonDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, USA.ORCID 0000-0001-7248-8787
Peter H SudmantDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-9573-8248
Erin MolloyDepartment of Computer Science, University of Maryland, College Park, MD, USA.ORCID 0000-0001-5553-3312
Erik GarrisonDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0003-3821-631X
Craig B LoweDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-6838-1976
Mario VenturaDepartment of Biosciences, Biotechnology and Environment, University of Bari, Bari, Italy.ORCID 0000-0001-7762-8777
Rachel J O'NeillInstitute for Systems Genomics, University of Connecticut, Storrs, CT, USA.ORCID 0000-0002-1525-6821
Sergey KorenGenome Informatics Section, Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1472-8962
Kateryna D MakovaDepartment of Biology, Penn State University, University Park, PA, USA. kdm16@psu.edu.ORCID 0000-0002-6212-9526
Adam M PhillippyGenome Informatics Section, Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. adam.phillippy@nih.gov.ORCID 0000-0003-2983-8934
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA. ee3@uw.edu.ORCID 0000-0002-8246-4014

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI RICHARD A MILLER · 2004 to 2026
$102.6M
Implementing the Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL)U24HG010263 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI Enis Afgan, VINCENT JAMES CAREY · 2018 to 2026
$23.8M
TRAINING PROGRAM IN COMPUTATIONAL BIOLOGY AND MEDICINET15LM007093 · NLM · RICE UNIVERSITY · PI Lydia E. Kavraki · 1992 to 2026
$20.8M
GENCODE Resource ProjectU41HG007234 · NHGRI · SANGER INSTITUTE · PI FLICEK, PAUL · 2013 to 2020
$20.3M
Identifying and Characterizing the Full Spectrum of Haplotype-resolved Structural Variation in Human GenomesU24HG007497 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Evan Eichler, Jan Oliver Korbel · 2019 to 2026
$17.2M
Sequence and Assembly of Segmental DuplicationsR01HG002385 · NHGRI · UNIVERSITY OF WASHINGTON · PI Evan Eichler · 2001 to 2026
$13.3M
Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO, SAVIDGE, TOR C. · 2020 to 2025
$12.0M
TRAINING GRANT IN GENETICST32GM007748 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Anne O'Donnell-Luria, Louise Wilkins-Haug · 1985 to 2026
$12.0M
Statistical Methods for Gene Regulatory Analysis From Single Cell Genomics DataP20GM139769 · NIGMS · CLEMSON UNIVERSITY · PI ALEXANDROV, ANDREI · 2021 to 2025
$10.8M
Sequence-resolved structural variation of human genomesR01HG010169 · NHGRI · UNIVERSITY OF WASHINGTON · PI Evan Eichler · 2018 to 2026
$4.5M
Genomic and Physiological Impact of Transposable Elements.R35GM122550 · NIGMS · CORNELL UNIVERSITY · PI Cedric Feschotte · 2017 to 2026
$4.4M
NCI NIH HHS R01 CA266339NHGRI NIH HHS R01 HG002385NHGRI NIH HHS R01 HG007352NHGRI NIH HHS R01 HG010169NHGRI NIH HHS R01 HG010329NHGRI NIH HHS R01 HG014490NHGRI NIH HHS R35 HG011332NHGRI NIH HHS T32 HG012344NHGRI NIH HHS U24 HG007497NHGRI NIH HHS U24 HG010263NHGRI NIH HHS U41 HG007234NIAID NIH HHS P01 AI152999NIA NIH HHS R01 AG056169NIA NIH HHS R56 AG056169NIA NIH HHS U19 AG023122NIA NIH HHS UH2 AG064706NIA NIH HHS UH3 AG064706NIGMS NIH HHS P20 GM139769NIGMS NIH HHS R01 GM123312NIGMS NIH HHS R35 GM122550NIGMS NIH HHS R35 GM133600NIGMS NIH HHS R35 GM133747NIGMS NIH HHS R35 GM142916NIGMS NIH HHS R35 GM146886NIGMS NIH HHS R35 GM146926NIGMS NIH HHS R35 GM151348NIGMS NIH HHS R35 GM151945NIGMS NIH HHS T32 GM007748NIH HHS P51 OD011092NIMH NIH HHS R01 MH120295NLM NIH HHS T15 LM007093
6 · The paper itself

Abstract

The most dynamic and repetitive regions of great ape genomes have traditionally been excluded from comparative studies

Indexed as

HominidaeWhole Genome SequencingAnimalsCentromereChromosomes, MammalianEvolution, MolecularGenomeGorilla gorillaHaplotypesHeterochromatinHumansPan paniscusPan troglodytesPhylogenySegmental Duplications, GenomicTelomereHeterochromatin

Identifiers

PMID40205052
PMCPMC12058530

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.