ArticleNature2025
Towards accurate differential diagnosis with large language models.
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07337577 (Large Language Model-Generated Messages to Improve Guideline-Directed Medical Therapy in Heart Failure), which is not on this map. Cited by 154 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Large Language Model-Generated Messages to Improve Guideline-Directed Medical Therapy in Heart Failure
Who cites it
154 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Natural language generation in healthcare: A review of methods and applications.Journal of biomedical informatics · 2026Pooled it
- LLM-assisted systematic review of large language models in clinical medicine.Nature medicine · 2026Pooled it
- Artificial intelligence in rehabilitation: a living systematic mapping review - first release.European journal of physical and rehabilitation medicine · 2025Pooled it
- Real-Time Artificial Intelligence Diagnostic Copilot in Simulated Primary Care Consultations: Randomized Simulation Study.JMIR formative research · 2026Trial
- Large language models enhance diagnostic reasoning of medical students in rheumatology: a randomized controlled trial.BMC medical education · 2026Trial
- An LLM chatbot to facilitate primary-to-specialist care transitions: a randomized controlled trial.Nature medicine · 2026Trial
- A large language model for complex cardiology care.Nature medicine · 2026Trial
- An eyecare foundation model for clinical assistance: a randomized controlled trial.Nature medicine · 2025Trial
- Trial
- GPT-4 assistance for improvement of physician performance on patient care tasks: a randomized controlled trial.Nature medicine · 2025Trial
- Large Language Model Influence on Diagnostic Reasoning: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Enthusiasm and structural frustration? Insights from an exploratory cross-sectional two-cohort study into career decision-making and retention factors in German neurology.BMC medical education · 2026Article
- The 5R's of large language model-assisted diagnosis: A practical framework for hospitalists.Journal of hospital medicine · 2026Article
- Optimizing generative artificial intelligence for clinical summarization: a blinded comparison study of automated versus human care planning synopses.JAMIA open · 2026Article
- Perspectives on the Limits and Clinical Alignment of Medical AI from Population Statistics to Individual Care.Bioengineering (Basel, Switzerland) · 2026Article
- Unmasking bias in the evidence ecosystem: a panoramic analysis of 311,751 meta-analyses using an artificial intelligence agent-based approach.Journal of global health · 2026Article
- aiDIVA - hybrid AI for rare disease diagnostics using evidence-based, machine learning and language models.NPJ genomic medicine · 2026Article
- Generative AI and Clinicians Show Comparable Prognostic Reasoning From Clinical Narratives in Biologic-Treated CRSwNP.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- From Chatbots to Co-Scientists: The Impact of Knowledge-Generating AI (AI 4.0) on Healthcare and Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
Abstract
A comprehensive differential diagnosis is a cornerstone of medical care that is often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive interfaces powered by large language models present new opportunities to assist and automate aspects of this process
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.