Evidence map›Paper›PMID 40205046›Full record

ArticleNature2025

Goal-specific hippocampal inhibition gates learning.

Nuri Jeong, Xiao Zheng, Abigail L Paulson, Stephanie M Prince, Victor P Nguyen, Sherina R Thomas, Caroline E Gilpin, Matthew C Goodson, Annabelle C Singer

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nuri Jeong *Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0003-0667-1879
Xiao Zheng *Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Abigail L PaulsonCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Stephanie M PrinceCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Victor P NguyenCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Sherina R ThomasCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Caroline E GilpinCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Matthew C GoodsonCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Annabelle C SingerCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA. asinger@gatech.edu.ORCID 0000-0001-6003-0488

Funding

TRAINING IN TRANSLATIONAL RESEARCH IN NEUROLOGYT32NS007480 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2000 to 2020
$4.5M
Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
Non-Invasive Methods to Drive Neural Activity with Millisecond Precision and to Recruit the Brain’s Immune CellsR01NS109226 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Annabelle Catherine Singer · 2018 to 2026
$2.7M
Hippocampal interneurons in novel memory formation in health and Alzheimer's diseaseRF1AG078736 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGER, ANNABELLE CATHERINE · 2022 to 2025
$2.5M
Gamma Sensory Flicker as an Early Intervention for Alzheimer’s Disease: Mechanisms and Protective EffectsRF1NS109226 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGER, ANNABELLE CATHERINE · 2023 to 2024
$2.2M
Effects of non-invasive gamma stimulation on hippocampal neural codes in a mouse model of Alzheimer’s diseaseF31AG066410 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI PAULSON, ABIGAIL LYNN · 2019 to 2021
$137k
NIA NIH HHS F31 AG066410NIA NIH HHS RF1 AG078736NINDS NIH HHS R01 NS109226NINDS NIH HHS RF1 NS109226NINDS NIH HHS T32 NS007480NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

Goal-directed navigation in a new environment requires quickly identifying and exploiting important locations. Identifying new goal locations depends on neural computations that rapidly represent locations and connect location information to key outcomes such as food

Indexed as

CA3 Region, HippocampalGoalsHippocampusLearningNeural InhibitionAnimalsFemaleFoodFood DeprivationInterneuronsMaleMiceMice, Inbred C57BLOptogeneticsParvalbuminsRewardParvalbumins

Identifiers

PMID40205046
PMCPMC12222015

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.