Evidence map›Paper›PMID 40205045›Full record

ArticleNature2025

Spatial multi-omics reveals cell-type-specific nuclear compartments.

Yodai Takei, Yujing Yang, Jonathan White, Isabel N Goronzy, Jina Yun, Meera Prasad, Lincoln J Ombelets, Simone Schindler, Prashant Bhat, Mitchell Guttman and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Review
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  10. Article
  11. Article
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  13. Review
  14. Genome-wide chromatin recording resolves dynamic cell state changes.bioRxiv : the preprint server for biology · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Resolving Sub-Nuclear Architecture from Compartments to Functional Domains.International journal of molecular sciences · 2026
    Review
  19. Review
  20. A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yodai Takei *Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. ytakei@caltech.edu.ORCID 0000-0002-7226-5185
Yujing Yang *Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jonathan WhiteDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-7009-3332
Isabel N GoronzyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jina YunDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Meera PrasadDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Lincoln J OmbeletsDana-Farber Cancer Institute, Boston, MA, USA.
Simone SchindlerWashington University, St. Louis, MO, USA.ORCID 0000-0003-1028-3115
Prashant BhatDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0003-3832-4871
Mitchell GuttmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0003-4748-9352
Long CaiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. lcai@caltech.edu.ORCID 0000-0002-7154-5361

Funding

Dynamics of chromosome organization and chromatin states in single cellsU01DK127420 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CAI, LONG, ELOWITZ, MICHAEL B · 2020 to 2024
$5.7M
NIDDK NIH HHS U01 DK127420
6 · The paper itself

Abstract

The mammalian nucleus is compartmentalized by diverse subnuclear structures. These subnuclear structures, marked by nuclear bodies and histone modifications, are often cell-type specific and affect gene regulation and 3D genome organization

Indexed as

Cell NucleusGenomicsAnimalsCerebellumChromatinFemaleGenomeHeterochromatinHistonesMaleMiceMultiomicsNeuronsOrgan SpecificityRNA Polymerase IISingle-Cell AnalysisChromatinHeterochromatinHistonesRNA Polymerase II

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.