SynthesisNature2025
Translational genomics of osteoarthritis in 1,962,069 individuals.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic architecture of lumbar spinal stenosis.Nature communications · 2026Pooled it
- Chondrogenic niche hydrogel microspheres facilitate cartilage regeneration in osteoarthritis.Bioactive materials · 2026Article
- Immunity-and-matrix-regulatory cells promote hyaline-like cartilage repair in osteoarthritis.Bioactive materials · 2026Article
- Recent advances in understanding molecular and clinical heterogeneity in osteoarthritis: one disease or several?Osteoarthritis imaging · 2026Article
- The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- T Cells in Osteoarthritis: Drivers, Repairers, or Bystanders in Osteoarthritis?Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis.Bone research · 2026Article
- Single-cell and spatial transcriptomics analysis of osteoarthritis: pathway regulation, cell interaction networks, and therapeutic translation.Journal of translational medicine · 2026Review
- Unveiling the BMI Risk Threshold for Osteoarthritis: Multi-Database Causal and Nonlinear Evidence.Diabetes, obesity & metabolism · 2026Article
- Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging.Cell genomics · 2026Review
- [Osteoarthritis: epidemiology, pathophysiology, and conservative treatment options].Innere Medizin (Heidelberg, Germany) · 2026Review
- The ClockJournal of orthopaedic surgery and research · 2026Article
- Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genes.Nature communications · 2026Article
- Dissecting the genetic architecture of knee alignment reveals its contribution to osteoarthritis risk.medRxiv : the preprint server for health sciences · 2026Article
- Defining the Impact of Genetics on Equine Performance and Development of Orthopaedic Disease.Animals : an open access journal from MDPI · 2026Review
- What's New in Spine Surgery.The Journal of bone and joint surgery. American volume · 2026Article
- Liposomal multimodal theranostics for bone disorders: from rational responsive delivery and biomimetic strategies to clinical translation.Journal of nanobiotechnology · 2026Review
- Human hip osteoarthritis-associatedbioRxiv : the preprint server for biology · 2026Article
- Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum.Nature communications · 2026Article
- Osteoarthritis phenotypes: advancing precision medicine through clinical, structural, and molecular stratification.International orthopaedics · 2026Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
182 authors.
Konstantinos Hatzikotoulas *Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-4699-3672
Lorraine Southam *Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Lilja Stefansdottir *deCODE Genetics/Amgen, Reykjavik, Iceland.
Cindy G Boer *Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands.
Merry-Lynn McDonald *Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.
J Patrick PettWellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-5249-444X
Young-Chan ParkInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Margo TuerlingsDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Rick MuldersDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-6151-0595
Andrei BarysenkaInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Ana Luiza ArrudaInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Vinicius TragantedeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0002-8223-8957
Alison RoccoBirmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.
Norbert BittnerInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-8588-185X
Shibo ChenInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Susanne HornInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-2902-0377
Vinodh SrinivasasainagendraBirmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.
Ken ToWellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK.
Georgia KatsoulaInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Peter KreitmaierInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Amabel M M TengheCentre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany.ORCID 0000-0002-3799-1907
Arthur GillyRegeneron Genetics Center, Tarrytown, NY, USA.
Liubov ArbeevaThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-5004-419X
Lane G ChenDepartment of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong.ORCID 0000-0002-7761-2334
Agathe M de PinsIcahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9988-8967
Daniel DochtermannBirmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.ORCID 0000-0001-9513-5124
Cecilie HenkelClinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.ORCID 0000-0002-4219-5374
Jonas HöijerMedical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Shuji ItoDepartment of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan.
Penelope A LindPsychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0002-3887-2598
Bitota Lukusa-SawalenaBirmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.
Aye Ko Ko MinnTohoku University Graduate School of Medicine, Sendai, Japan.
Marina Mola-CaminalMedical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-0122-9096
Akira NaritaTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.ORCID 0000-0002-9076-0710
Chelsea NguyenBirmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.ORCID 0000-0003-0674-7423
Ene ReimannEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Micah D SilbersteinCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Anne-Heidi SkogholtHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0001-7466-0405
Hemant K TiwariDepartment of Biostatistics, School of Public Health, UAB, Birmingham, AL, USA.
Michelle S YauHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA.
Ming YueSchool of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong.ORCID 0000-0002-4052-818X
Wei ZhaoSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7388-0692
Jin J ZhouDepartment of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
George Alexiadis1st Department of Orthopaedics, KAT General Hospital, Athens, Greece.
Karina BanasikNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Søren BrunakNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0316-5866
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-0198-5078
Jackson T S CheungFaculty of Medical Sciences, University College London, London, UK.
Joseph DowsettDepartment of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-5381-2633
Tariq FaquihDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Lijiang FeiWellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK.
Anne Marie FenstadThe Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway.
Takamitsu FunayamaTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Maiken E GabrielsenHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Chinatsu GochoTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Kirill GromovClinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Thomas HansenDanish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet - Glostrup, Glostrup, Denmark.ORCID 0000-0001-6703-7762
Georgi HudjashovEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Thorvaldur IngvarssonDepartment of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland.
Jessica S JohnsonPamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Helgi JonssonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Saori KakehiDepartment of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Juntendo University, Tokyo, Japan.ORCID 0000-0002-1280-2882
Juha KarjalainenInstitute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Elisa KasbohmInstitute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0001-5261-538X
Susanna LemmeläInstitute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Kuang LinNuffield Department of Population Health, University of Oxford, Oxford, UK.
Xiaoxi LiuLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Marieke LoefDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.ORCID 0000-0002-2167-7470
Daniel McCartneyCentre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK.
Iona Y MillwoodNuffield Department of Population Health, University of Oxford, Oxford, UK.
Joshua RichmanBirmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.
Mary B RobertsCenter for Primary Care & Prevention, Brown University, Pawtucket, RI, USA.
Kathleen A RyanDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Dino SamartzisDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China.
Manu ShivakumarDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4733-7375
Søren T SkouResearch Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.ORCID 0000-0003-4336-7059
Sachiyo SugimotoTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Ken SuzukiCentre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.
Hiroshi TakuwaDepartment of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan.
Maris Teder-LavingEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5872-1850
Laurent ThomasHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-0548-2486
Kohei TomizukaLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Constance TurmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-7790-8311
Stefan WeissDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-3553-4315
Tian T WuDepartment of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Eleni Zengini4th Psychiatric Department, Dromokaiteio Psychiatric Hospital, Haidari, Athens, Greece.
Yanfei ZhangGenomic Medicine Institute, Geisinger Health System, Danville, PA, USA.
arcOGEN Consortium
ARGO Consortium
DBDS Genomic Consortium
Estonian Biobank Research Team
FinnGen
Genes & Health Research Team
HUNT All-In Pain
Million Veteran Program
Regeneron Genetics Center
Manuel Allen Revez FerreiraRegeneron Genetics Center, Tarrytown, NY, USA.ORCID 0000-0001-9059-1825
George Babis2nd Department of Orthopaedics, National and Kapodistrian University of Athens, Medical School, 'Konstantopouleio' Hospital, Athens, Greece.
Aris BarasRegeneron Genetics Center, Tarrytown, NY, USA.ORCID 0000-0002-6830-3396
Tyler BarkerSports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
David J CareyDepartment of Genomic Health, Geisinger, Danville, PA, USA.
Kathryn S E CheahSchool of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong.ORCID 0000-0003-0802-8799
Zhengming ChenNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0001-6423-105X
Jason Pui-Yin CheungDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-7052-0875
Mark DalyInstitute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Charles B EatonCenter for Primary Care & Prevention, Brown University, Pawtucket, RI, USA.
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-6551-6647
Ove Nord FurnesThe Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0001-8223-2515
Yvonne M GolightlyThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Daniel F GudbjartssondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0002-5222-9857
Nils P HailerOrthopedics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Caroline HaywardMRC Human Genetics Unit IGC, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9405-9550
Marc C HochbergDepartment of Epidemiology and Public Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Georg HomuthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0001-6839-0605
Laura M HuckinsDepartment of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, USA.ORCID 0000-0002-5369-6502
Kristian HveemHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Shiro IkegawaLaboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.ORCID 0000-0003-0316-2147
Muneaki IshijimaDepartment of Medicine for Orthopaedics and Motor Organ, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Minoru IsomuraFaculty of Human Sciences, Shimane University, Matsue, Japan.
Marcus JonesRegeneron Genetics Center, Tarrytown, NY, USA.
Jae H KangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Margreet KloppenburgDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-9294-2307
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nobuyuki KumahashiDepartment of Orthopedic Surgery, Matsue Red Cross Hospital, Matsue, Japan.
Suguru KuwataDepartment of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan.ORCID 0009-0009-3176-1906
Ming Ta Michael LeeGenomic Medicine Institute, Geisinger Health System, Danville, PA, USA.
Phil H LeeCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-1770-3100
Robin LernerBlizard Institute, Queen Mary University of London, London, UK.
Liming LiDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID 0000-0001-5873-7089
Steve A LietmanMusculoskeletal Institute, Geisinger, Danville, PA, USA.
Luca LottaRegeneron Genetics Center, Tarrytown, NY, USA.
Michelle K LuptonSchool of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-2964-6011
Nicholas G MartinGenetic Epidemiology, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-4069-8020
Timothy E McAlindonDivision of Rheumatology, Allergy, & Immunology, Tufts Medical Center, Boston, MA, USA.
Sarah E MedlandPsychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-1382-380X
Karl MichaëlssonMedical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2815-1217
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4920-4744
Dennis O Mook-KanamoriDepartment of Public Health, Leiden University Medical Center, Leiden, The Netherlands.
Andrew P MorrisInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-6805-6014
Toru NabikaDepartment of Functional Pathology, Shimane University School of Medicine, Izumo, Japan.
Fuji NagamiTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Amanda E NelsonThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-9344-7877
Sisse Rye OstrowskiDepartment of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-5288-3851
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-2527-5874
Ole Birger PedersenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2312-5976
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-2558-7496
Mika Sakurai-YagetaTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Carsten Oliver SchmidtInstitute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0001-5266-9396
Pak Chung ShamLi Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.ORCID 0000-0002-2533-7270
Jasvinder A SinghBirmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.
Diane T SmelserDepartment of Genomic Health, Geisinger, Danville, PA, USA.
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3575-5468
You-Qiang SongSchool of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong.ORCID 0000-0001-9407-2256
Erik SørensenDepartment of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-5002-9077
Gen TamiyaTohoku University Graduate School of Medicine, Sendai, Japan.
Yoshifumi TamuraDepartment of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0002-1685-7821
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.ORCID 0000-0002-6452-4095
Gudmar ThorleifssondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0003-4623-9087
Anders TroelsenClinical Academic Group: Research OsteoArthritis Denmark (CAG ROAD), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Aspasia TsezouLaboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, University of Thessaly, Larissa, Greece.
Yuji UchioDepartment of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan.ORCID 0000-0002-5858-9861
A G UitterlindenDepartment of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-7276-3387
Henrik UllumStatens Serum Institute, Copenhagen, Denmark.
Ana M ValdesFaculty of Medicine & Health Sciences, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0003-1141-4471
David A van HeelBlizard Institute, Queen Mary University of London, London, UK.ORCID 0000-0002-0637-2265
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-9179-0321
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1661-2402
J Mark WilkinsonSchool of Medicine and Population Health, The University of Sheffield, Sheffield, UK.
Bendik S WinsvoldHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-4171-8919
Masayuki YamamotoTohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0002-9073-9436
John-Anker ZwartHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0001-5721-0154
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Ingrid MeulenbeltDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-7786-7081
Sarah A TeichmannDepartment of Medicine & Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6294-6366
Joyce B J van MeursDepartment of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands.
Unnur StyrkarsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID 0000-0001-8146-8278
Eleftheria ZegginiInstitute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. eleftheria.zeggini@helmholtz-munich.de.ORCID 0000-0003-4238-659X
Funding
UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1MTraining Program in Rheumatic and Musculoskeletal Diseases ResearchT32AR069516 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2016 to 2026
$2.6MSystemic contribution of age-associated epigenetic mechanisms to osteoarthritisR01AR075356 · NIAMS · HEBREW REHABILITATION CENTER FOR AGED · PI YAU, MICHELLE SZU-HUEI · 2019 to 2022
$1.7MNCCDPHP CDC HHS U01 DP006266NIAMS NIH HHS P30 AR072580NIAMS NIH HHS R01 AR075356NIAMS NIH HHS T32 AR069516RRD VA I01 RX002745
Abstract
Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes
Indexed as
Genome-Wide Association StudyGenomicsOsteoarthritisTranslational Research, BiomedicalCase-Control StudiesEpigenomeFemaleHumansMaleNeurogliaProteomeSignal TransductionSingle-Cell AnalysisTranscriptomeProteome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.