ArticleNpj mental health research2025
Probiotics reduce negative mood over time: the value of daily self-reports in detecting effects.
Article in Npj mental health research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- The Effect of a Probiotic on Gut Microbiota Stability and Systemic Well-Being during Short-Term Travel.Journal of microbiology and biotechnology · 2026Trial
- A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress.BMC medicine · 2026Article
- Mapping research hotspots and trends in gut microbiota and autoimmune diseases since the 21st century: a bibliometric visualization analysis based on two databases.Frontiers in immunology · 2026Article
- From Bacillus Criminalis to the Legalome: Will Neuromicrobiology Impact 21st Century Criminal Justice?Brain sciences · 2025Article
- Probiotic effects on cognitive performance, hippocampal oxidative stress, and structural damage induced by icv STZ in Alzheimer-like rat model.Brain structure & function · 2025Article
- A comprehensive overview of the effects of probiotics, prebiotics and synbiotics on the gut-brain axis.Frontiers in microbiology · 2025Review
- The human microbiome in clinical translation: from bench to bedside.Frontiers in microbiology · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The burgeoning field of the microbiome-gut-brain axis has inspired research into how the gut microbiome can affect human emotion. Probiotics offer ways to investigate microbial-based interventions but results have been mixed, with more evidence of beneficial effects in clinically depressed patients. Using a randomised, double-blind, placebo-controlled design in 88 healthy volunteers, we conduct a comprehensive study into effects of a multispecies probiotic on emotion regulation and mood through questionnaires, emotional processing tests and daily reports. We find clear evidence that probiotics reduce negative mood, starting after two weeks, based on daily monitoring, but few other changes. Our findings reconcile inconsistencies of previous studies, revealing that commonly used pre- versus post-intervention assessments cannot reliably detect probiotic-induced changes in healthy subjects' emotional state. We conclude that probiotics can benefit mental health in the general population and identify traits of individuals who derive greatest benefit, allowing future targeting of at-risk individuals.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.