Evidence map›Paper›PMID 40204982›Full record

ArticleCellular and molecular life sciences : CMLS2025

Complementary approaches define the metabolic features that accompany Richter syndrome transformation.

Giulia Omezzolli, Andrea Iannello, Francesco E Vallone, Lorenzo Brandimarte, Matilde Micillo, Nadia Bertola, Chiara Lavarello, Nicole Grinovero, Giulio Ferrero, Kevin Mellert and 8 more

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In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Giulia Omezzolli *Department of Medical Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy.
Andrea Iannello *Department of Medical Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy.
Francesco E ValloneDepartment of Medical Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy.
Lorenzo BrandimarteDepartment of Medical Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy.
Matilde MicilloDepartment of Medical Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy.
Nadia BertolaU.O. Molecular Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Chiara LavarelloCore Facilities-Clinical Proteomics and Metabolomics, IRCCS Giannina Gaslini, Genoa, Italy.
Nicole GrinoveroCore Facilities-Clinical Proteomics and Metabolomics, IRCCS Giannina Gaslini, Genoa, Italy.
Giulio FerreroDepartment of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Kevin MellertInstitute of Pathology, University Hospital Ulm, Ulm, Germany.
Peter MöllerInstitute of Pathology, University Hospital Ulm, Ulm, Germany.
Silvia BrunoDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Richard R FurmanWeill Cornell Medicine, NewYork-Presbyterian Hospital, New York, NY, USA.
John N AllanWeill Cornell Medicine, NewYork-Presbyterian Hospital, New York, NY, USA.
Andrea PetrettoCore Facilities-Clinical Proteomics and Metabolomics, IRCCS Giannina Gaslini, Genoa, Italy.
Silvia DeaglioDepartment of Medical Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy.
Silvia RaveraDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Tiziana VaisittiDepartment of Medical Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy. tiziana.vaisitti@unito.it.ORCID http://orcid.org/0000-0002-3375-6985

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia (CLL) into a high-grade lymphoma with previously unknown metabolic features. Transcriptomic data from primary CLL and RS samples, as well as RS-patient-derived xenografts, highlighted cellular metabolism as one of the most significant differentially expressed processes. Activity assays of key enzymes confirmed the intense metabolic rewiring of RS cells, which is characterized by an elevated rate of Krebs cycle, oxidative phosphorylation, and glutamine metabolism. These pathways were sustained by increased uptake of glucose and glutamine, two critical substrates for these cells. Moreover, RS cells showed activation of anabolic processes that resulted in the synthesis of nucleotides and lipids necessary to support their high proliferation. Exposure to drugs targeting PI3K and NF-kB, two master regulators of cellular metabolism, resulted in the shutdown of ATP production and glycolysis. Overall, these data suggest that metabolic rewiring characterizes the transformation of CLL into RS, presenting new translational opportunities.

Indexed as

Cell Transformation, NeoplasticLeukemia, Lymphocytic, Chronic, B-CellAnimalsCitric Acid CycleGlucoseGlutamineGlycolysisHumansMiceNF-kappa BOxidative PhosphorylationPhosphatidylinositol 3-KinasesGlucoseGlutamineNF-kappa BPhosphatidylinositol 3-KinasesBuilding blocksChronic lymphocytic leukemiaMetabolic dependenciesMetabolic rewiringMetabolic targetingRichter transformation

Identifiers

PMID40204982
PMCPMC11982009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.