ArticleCommunications medicine2025
Improvements induced by retinal gene therapy with voretigene neparvovec depend on visual cortical hemispheric dominance mechanisms.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- The Role of miRNAs in Retinal Physiology and in Inherited Retinal Disorders.Physiology (Bethesda, Md.) · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundRPE65-associated retinal degeneration (RPE65-RD) causes severe visual deficits. Gene therapy with AAV2-hRPE65v2 is a breakthrough but it is currently unknown which visual pathways benefit from treatment and if cortical mechanisms can amplify retinal improvements.
methodsIn this within-subject design, ten patients with biallelic RPE65-RD underwent sub-retinal injection of AAV2-hRPE65v2. Psychophysical full-field stimulus threshold determination and functional magnetic resonance imaging were performed before and 12 months after treatment. Population receptive fields (pRF) were computed in V1 and visual responses assessed using contrast-reversed checkerboards (3 contrast levels).
resultsHere we show significant improvement in light sensitivity at low-luminance and neural response enhancements under low-luminance conditions specifically in the right hemisphere, which is known to show dominance in attentional and visual pooling of spatial information. Changes in pRF size also reflect known hemispheric spatial asymmetries (left/right biased for local/global analysis, respectively).
conclusionsOur findings show a contribution of known early and high-level cortical dominance mechanisms on improvement, which constrain the effects of therapy and are therefore a target for neurorehabilitation. These findings provide insight into the limits of clinical benefits of gene therapy and suggest that neurorehabilitation approaches may be needed to enhance improvements, similarly to cochlear implants.
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Registered trials
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