ArticleScientific reports2025
Monocyte-to-HDL cholesterol ratio (MHR) as a novel Indicator of gout risk.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unravelling the link between chronic inflammation and primary hyperparathyroidism: a systematic review.Frontiers in immunology · 2025Pooled it
- Sex-Specific Associations of Monocyte-Based Inflammatory Indices with Renal Dysfunction and Hyperuricemia in the Saudi General Adult Population.Healthcare (Basel, Switzerland) · 2026Article
- Association between monocyte to high-density lipoprotein cholesterol ratio and thyroid function: a cross-sectional study.Scientific reports · 2025Article
- Association between monocyte-to-HDL ratio and Fazekas-scaled white matter hyperintensities in migraine patients: a cross-sectional MRI-based study.Frontiers in neurology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Gout, a common inflammatory arthritis, is associated with elevated monocyte levels and reduced high-density lipoprotein cholesterol (HDL-C). However, the relationship between the monocyte-to-HDL-C ratio (MHR) and gout risk remains unexplored. This study investigates the association between MHR and gout risk, examines the role of MHR in gout with comorbid renal dysfunction, and provides a theoretical basis for gout prevention and treatment. Using data from the National Health and Nutrition Examination Survey (NHANES, 2005-2016), a cross-sectional analysis was conducted to assess the correlation between MHR levels and gout. Multiple logistic regression, subgroup analyses, and exploration of nonlinear relationships were employed. Among 7247 participants, MHR was significantly higher in gout patients (0.54 ± 0.31) compared to non-gout patients (0.47 ± 0.24). After adjustments, MHR was significantly associated with gout risk (OR = 1.6, 95%CI 1.1-2.2, P = 0.012). Subgroup analyses revealed a positive correlation between MHR and gout risk in males, Mexican Americans, married individuals, those with insufficient physical activity, and diabetic patients. In gout patients with renal dysfunction, MHR was 0.6 ± 0.5, showing a stronger positive association (OR = 7.4, 95%CI 2.2-25.3, P = 0.001). The prevalence of gout with renal dysfunction in the highest MHR quartile was 1.7 times higher than in the lowest quartile (OR = 2.7, 95%CI 1.1-6.7, P = 0.028). These findings suggest a significant positive correlation between MHR and gout risk in U.S. adults, as well as a link between MHR and the severity of renal dysfunction in gout patients. MHR may serve as a valuable indicator for assessing gout risk and its complications, highlighting the need for further large-scale prospective studies to confirm these results.
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