ArticleJournal of neurology2025
Clinical and MRI features contributing to the clinico-radiological dissociation in a large cohort of people with multiple sclerosis.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Progressive motor impairment from intracerebral critical demyelinating lesions.Journal of neurology · 2026Article
- The relationship between cerebellar functional connectivity alterations and hand dexterity impairment in multiple sclerosis.Journal of neurology · 2026Article
- Big data in multiple sclerosis.Current opinion in neurology · 2026Review
- Clinical and MRI substrates of Symbol Digit Modalities Test impairment in multiple sclerosis patients with an adult- and late-onset.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Heterogeneous Deep Gray Matter Iron Deposition Patterns across Multiple Sclerosis Subgroups Defined by the Clinico-Radiological Paradox.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- TMS-EEG signatures of motor network dysfunction in multiple sclerosis.Brain communications · 2026Article
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Authors and funding
17 authors.
Funding
Abstract
backgroundPeople with Multiple Sclerosis (PwMS) often show a mismatch between disability and T2-hyperintense white matter (WM) lesion volume (LV), that in general is referred to as the clinico-radiological paradox.
objectivesThis study aimed to understand how an extensive clinical, neuropsychological, and MRI analysis could better elucidate the clinico-radiological dissociation in a large cohort of PwMS.
methodsClinical scores, such as Expanded Disability Status Scale (EDSS), 9 Hole Peg Test (9HPT), 25-foot Walking Test (25-FWT), Paced Auditory Serial Addition Test at 3 s (PASAT3), Symbol digit Modalities Test (SDMT), demographics, and 3 T-MRI of 717 PwMS and 284 healthy subjects (HS) were downloaded from the INNI database. Considering medians of LV and EDSS scores, PwMS were divided into four groups: low LV and disability (LL/LD); high LV and low disability (HL/LD); low LV and high disability (LL/HD); high LV and disability (HL/HD). MRI measures included: volumes of gray matter (GM), WM, cerebellum, basal ganglia and thalamus, spinal cord (SC) area, and functional connectivity of resting-state networks.
resultsThe clinico-radiological dissociation involved 36% of our sample. HL/LD showed worse SDMT scores and lower global and deep GM volumes than HS and LL/LD. LL/HD showed lower GM, thalamus, and cerebellum volumes, and SC area than HS, and lower SC area than LL/LD.
conclusionsA more extensive clinical assessment, including cognitive tests, and MRI evaluation including deep GM and SC, could better describe the real status of the disease and help clinicians in early and tailored treatment in PwMS.
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