Observational studyBritish journal of cancer2025
In-utero and newborn factors and thyroid cancer incidence in adult women in the Sister Study cohort.
Observational study in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Thyroid Under Pressure: Heavy Metals, Endocrine Disruptors and Translational Insights into Carcinogenesis and Thyroid Dysfunctions.International journal of molecular sciences · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
backgroundThyroid cancer is diagnosed at relatively young ages compared to other adult cancers, for reasons that remain unclear. Our study aimed to investigate associations of in-utero and newborn characteristics with differentiated thyroid cancer (DTC) incidence in adult women.
methodsFrom the U.S. nationwide Sister Study cohort, we included 47,913 cancer-free women at baseline (2003-2009). We assessed associations of participants' in-utero and newborn characteristics and DTC during follow-up using Cox regression models adjusted for attained age (timescale) and race/ethnicity.
resultsDuring follow-up (median = 13.1 years), 239 incident DTC cases were identified. Higher DTC incidence was associated with maternal pre-pregnancy or gestational diabetes (hazard ratio [HR] = 2.36, 95%CI = 0.97-5.74, 5 affected cases), gestational hypertension or hypertension-related disorders (HR = 1.99, 95%CI = 1.20-3.32, 16 affected cases), and higher birth weight (HR per kg=1.24, 95%CI = 0.95-1.60). Births occurring at least two weeks before the due date were associated with lower DTC incidence (HR = 0.47, 95%CI = 0.23-0.97, 8 affected cases). In a model simultaneously adjusted for all these factors, all exposures remained associated with DTC incidence. We observed no associations for other in-utero and newborn characteristics.
conclusionsThese findings contribute to a growing body of evidence that in-utero exposures related to maternal metabolic abnormalities may influence thyroid cancer risk later in life.
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