Cell polarity: cell type-specific regulators, common pathways, and polarized vesicle transport.

Cell polarity, the asymmetric organization of cellular components, is evolutionarily conserved from unicellular and multicellular organisms and is crucial for many biological processes. Polarity is required to maintain cell and tissue integrity by regulating cell division, migration, orientation, cell-cell interactions, and morphogenesis. Impaired polarity leads to dysregulation of cellular functions and is associated with disease. Understanding how polarity is established, maintained, and regulated is thus critical to improving our knowledge of pathologies and devising novel therapies. Here, we explore the various manifestations of cell polarity across different model systems, tissues, and cell types and focus on known polarity mechanisms in hematopoietic stem and progenitor cells. We discuss how cells with vastly different functions utilize conserved molecular complexes to establish cell polarity while adapting polarity proteins to unique cell-type-specific functions. In this discussion, we attempt to extract common themes and concepts to improve our understanding of cell polarity in hematological malignancies and other diseases. Finally, we summarize, compare, and evaluate classical as well as recently developed methods to quantify cell polarity, highlight important advances in imaging and analytical techniques, and suggest critical next steps required to move the field forward.