ArticleScientific reports2025
Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Mechanical Ventilation-Associated Changes in Hippocampal Electroencephalogram: A Cross-Species Study in Humans and Rats.CNS neuroscience & therapeutics · 2026Article
- Nasal and oral breathing modes reconfigure brain network dynamics between stabilizing integration and promoting fragmentation.Scientific reports · 2026Article
- Article
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Authors and funding
5 authors.
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Abstract
Mechanical ventilation (MV) causes a wide range of cognitive impairments. Unfortunately, to date, we are lacking knowledge about its underlying neural mechanisms and significant treatment options for the condition. Here, we show that MV-induced memory impairment in rats stems from dysfunctions in the olfactory bulb-medial prefrontal cortex-ventral hippocampus network and hippocampal synaptic currents imbalance. More importantly, we introduce a novel treatment approach, namely olfactory epithelium electrical stimulation (OEES) that shows promising preclinical results in mitigating the mentioned behavioral and neural disorders caused by MV. These results pave the way for research on non-invasive brain stimulation approaches and introduce the olfactory system as a potential target for treating cognitive or psychiatric disorders induced by MV.
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Registered trials
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