ArticleScientific reports2025
The impact of biological variables on cell kinetics and differentiation dynamics in the mouse incisor epithelium.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Kdf1 missense mutation caused enamel defects by disrupting cell adhesion and Hippo-YAP signaling in dental epithelium.International journal of oral science · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse incisor is a key model system for understanding the regulatory mechanisms governing dental stem cells (SCs). However, the effects of sex, age and strain on mouse incisor morphology and epithelial SC function remain unclear. We used micro-computed tomography and histology to analyze the apical region in males and females, two age groups, and two commonly used strains. Cell kinetics, enamel density, and volume were assessed to determine their impact on SC behavior and enamel properties. No differences were found in cell kinetics or enamel properties between male and female mice at 8 weeks of age. However, 3-week-old mice exhibited higher cell proliferation, lower enamel density, and reduced volume than 8-week-olds, highlighting age-dependent changes in SC activity and enamel formation. Additionally, strain-specific variations were observed, with ICR mice showing increased numbers of preameloblasts and higher enamel volume with lower density when compared to C57BL/6 mice at 8 weeks old. Our results establish a standardized framework for the examination of mouse incisor epithelial SCs. These standards will enhance research reproducibility and consistency, facilitate constructive critique by reviewers, and enable a deeper understanding of the complex factors influencing SC behavior across diverse physiological contexts.
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Registered trials
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