Evidence map›Paper›PMID 40204782›Full record

ArticleNature communications2025

Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca

Wei-Yin Lin, Woo Young Chung, Seonghee Park, Ava Movahed Abtahi, Benjamin Leblanc, Malini Ahuja, Shmuel Muallem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei-Yin LinThe Epithelial Signaling and Transport Section and The National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Woo Young ChungThe Epithelial Signaling and Transport Section and The National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0009-0008-6645-2815
Seonghee ParkDepartment of Physiology, Ewha Womans University College of Medicine, Seoul, Korea.
Ava Movahed AbtahiThe Epithelial Signaling and Transport Section and The National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1017-6128
Benjamin LeblancThe Epithelial Signaling and Transport Section and The National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Malini AhujaThe Epithelial Signaling and Transport Section and The National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Shmuel MuallemThe Epithelial Signaling and Transport Section and The National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. shmuel.muallem@nih.gov.ORCID http://orcid.org/0000-0002-6189-4947

Funding

Mass Spectrometry FacilityZIADE000751 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI WANG, YAN · 2019 to 2019
$193k
Intramural NIH HHS ZIA DE000751
6 · The paper itself

Abstract

ANO1 plays a crucial role in determining numerous physiological functions, including epithelial secretion, yet its regulatory mechanisms remain incompletely understood. Here, we describe a fundamental dynamic regulation of ANO1 surface expression and Ca

Indexed as

Anoctamin-1CalciumCell MembraneCyclic AMPCyclic AMP-Dependent Protein KinasesEndoplasmic ReticulumNeoplasm ProteinsStromal Interaction Molecule 1AnimalsHEK293 CellsHumansMiceMice, KnockoutPhosphorylationANO1 protein, humanANO1 protein, mouseAnoctamin-1CalciumCyclic AMPCyclic AMP-Dependent Protein KinasesNeoplasm ProteinsSTIM1 protein, humanStim1 protein, mouseStromal Interaction Molecule 1

Identifiers

PMID40204782
PMCPMC11982563

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.