ArticleNature communications2025
Multiplexed subspaces route neural activity across brain-wide networks.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- Generative AI as a transformational logic for cognitive neuroscience.Communications biology · 2026Review
- Behavior Differentially Shapes Spontaneous Cortical Network Dynamics Across Frequencies.bioRxiv : the preprint server for biology · 2026Article
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Noise-invariant representations of sound emerge along the canonical cortical hierarchy.PLoS biology · 2026Article
- The curriculum effect in visual learning: The role of readout dimensionality.PLoS computational biology · 2026Article
- A communication subspace relays context-dependent actions from human prefrontal to motor cortex.Nature neuroscience · 2026Article
- Independence and coherence in temporal sequence computation across the fronto-parietal network.Nature communications · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Input-dependent directionality of interactions between cortical areas.bioRxiv : the preprint server for biology · 2026Article
- Decomposing the modulation of interactions between neuronal populations.bioRxiv : the preprint server for biology · 2026Article
- Flexible integration of corollary discharge and sensory feedback signals in somatosensory cortex.bioRxiv : the preprint server for biology · 2026Article
- Live Spike Sorting of Large-scale Neural Recordings.bioRxiv : the preprint server for biology · 2026Article
- Article
- State-Dependent Dissociation of Shared Input and Directed Information Flow in the Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice.bioRxiv : the preprint server for biology · 2026Article
- Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification.bioRxiv : the preprint server for biology · 2025Article
- Inpainting the Neural Picture: Inferring Unrecorded Brain Area Dynamics from Multi-Animal Datasets.ArXiv · 2025Article
- Accurate Identification of Communication Between Multiple Interacting Neural Populations.ArXiv · 2025Article
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
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Abstract
Cognition is flexible, allowing behavior to change on a moment-by-moment basis. Such flexibility relies on the brain's ability to route information through different networks of brain regions to perform different cognitive computations. However, the mechanisms that determine which network of regions is active are not well understood. Here, we combined cortex-wide calcium imaging with high-density electrophysiological recordings in eight cortical and subcortical regions of mice to understand the interactions between regions. We found different dimensions within the population activity of each region were functionally connected with different cortex-wide 'subspace networks' of regions. These subspace networks were multiplexed; each region was functionally connected with multiple independent, yet overlapping, subspace networks. The subspace network that was active changed from moment-to-moment. These changes were associated with changes in the geometric relationship between the neural response within a region and the subspace dimensions: when neural responses were aligned with (i.e., projected along) a subspace dimension, neural activity was increased in the associated regions. Together, our results suggest that changing the geometry of neural representations within a brain region may allow the brain to flexibly engage different brain-wide networks, thereby supporting cognitive flexibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.