ArticleScientific data2025
An in vivo microscopy dataset for the characterization of leukocyte death.
Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Recent advancements in intravital microscopy have enabled the study of cell death in vivo under various experimental conditions, such as infection and cancer. However, the limited throughput of this technology, together with a lack of openly accessible datasets, affects the development of algorithms for the automatic detection and characterization of cell death, which in turn require the integration of extensive and curated datasets. To address these needs, we present a curated dataset of microscopy videos depicting the death of neutrophils, eosinophils, and dendritic cells, acquired in the spleen and in the lymph node of mice under inflammatory conditions. The dataset provides time-lapse imaging data, along with coordinates in space and time of cell death events displaying apoptotic-like morphodynamics, and 3D reconstruction of the cell morphology at each time point. Altogether, these data will be pivotal for developing computer vision and bioimage analysis methods to advance cell death research.
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