ArticleNature communications2025
Impact of perioperative organ injury on morbidity and mortality in 28 million surgical patients.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Effect of Ciprofol on Postoperative Cognitive Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial.Drug design, development and therapy · 2025Trial
- Preoperative Alanine Aminotransferase and Postoperative ALT Elevation: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- ARDS management in trauma patients.Intensive care medicine · 2026Review
- The clinical application of parenteral nutrition with Omega-3 fatty acids in patients after gastrectomy: a retrospective cohort study and cost-effectiveness analysis.Lipids in health and disease · 2026Article
- Delayed Ischemic Hepatocellular Injury Following Cemented Total Hip Arthroplasty: A Case Report Within the Spectrum of Bone Cement Implantation Syndrome.Life (Basel, Switzerland) · 2026Article
- Postoperative Delirium After Coronary Artery Bypass Grafting in the United States, 2016-2021: Trends, Risk Factors, and Outcomes.Journal of cardiothoracic and vascular anesthesia · 2026Observational
- Advantages of Ciprofol with Special Consideration of Pediatric Anesthesia.Children (Basel, Switzerland) · 2026Review
- Prioritizing perioperative organ injury prevention: a call to action from China's county-level hospitals.Frontiers in medicine · 2026Article
- The revised cardiac risk index and 90-day mortality after non-cardiac surgery: a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Sufentanil increases delirium risk compared to fentanyl in elderly perioperative ischemic stroke patients: a retrospective cohort study.Frontiers in medicine · 2026Article
- Perioperative Cardiac Complications and Evidence-Based Strategies for Their Management.Cureus · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Perioperative organ injury contributes to morbidity and mortality of surgical patients. This cohort study included all elective and emergent surgeries in Germany over 4 years to address the impact of perioperative organ injuries on outcomes. We analyzed 28,350,953 cases. In-hospital mortality was 1.4% (n = 393,157), and 4.4% of cases (n = 1,245,898) experienced perioperative organ injury. Perioperative organ injury was associated with 9-fold higher odds of death and prolonged hospital stay by 11.2 days. Acute kidney injury had the highest incidence (2.0%) and was associated with 25.0% mortality. While delirium had the second highest incidence (1.5%), it was associated with the lowest mortality (10.8%). This was followed by acute myocardial infarction (incidence 0.6%, mortality 15.6%), stroke (incidence 0.6%, mortality 13.1%), pulmonary embolism (incidence 0.3%, mortality 20.0%), liver injury (incidence 0.1%, mortality 68.7%), and acute respiratory distress syndrome (incidence 0.1%, mortality 44.7%). These findings help prioritize interventions for preventing or treating individual types of perioperative organ injury.
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