Evidence map›Paper›PMID 40204627›Full record

ArticleNMR in biomedicine2025

Measurement of Twitch Dynamics in Response to Exercise Induced Changes in Mitochondrial Disease Using Motor Unit Magnetic Resonance Imaging (MUMRI): A Proof-of-Concept Study.

Matthew G Birkbeck, Mathew Elameer, Linda Heskamp, Jane Newman, Renae J Stefanetti, Isabel Barrow, Oksana Pogoryelova, Gráinne S Gorman, Julie Hall, Ian S Schofield and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew G BirkbeckNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0001-6041-8052
Mathew ElameerNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0003-2557-4863
Linda HeskampNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-6828-9336
Jane NewmanWellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, UK.
Renae J StefanettiNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0001-6402-6435
Isabel BarrowNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.
Oksana PogoryelovaNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.
Gráinne S GormanNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-7585-3409
Julie HallWellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, UK.
Ian S SchofieldNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-1532-5049
Andrew M BlamireNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-8749-1257
Roger G WhittakerNewcastle University Translational and Clinical Research Institute (NUTCRI), Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-3403-0182

Funding

National Institute for Health and Care Research (NIHR)Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) 452183002NIHR Newcastle Biomedical Research CentreWellcome Trust
6 · The paper itself

Abstract

Muscle twitch dynamics and fatigability change in response to muscle disease. In this study, we developed an imaging paradigm to measure muscle twitch dynamics, and the response of the muscle to voluntary fatiguing contractions. We used a novel imaging technique called motor unit magnetic resonance imaging (MUMRI). MUMRI allows visualisation of muscle and motor unit activity by combining in-scanner electrical stimulation with dynamic pulsed gradient spin echo (twitch dynamics, PGSE-MUMRI) and phase contrast (fatigue, PC-MUMRI) imaging. In Part I of this study, we scanned 10 healthy controls, we measured the muscle rise (T

Indexed as

ExerciseMagnetic Resonance ImagingMitochondrial DiseasesAdultFemaleHumansMaleMiddle AgedMuscle ContractionMuscle, SkeletalProof of Concept StudyReproducibility of ResultsYoung Adultexercisefatiguemitochondrial diseasemotor unittwitch dynamics

Identifiers

PMID40204627
PMCPMC11981886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.